| Assessing basophil functional measures during monoclonal anti-IgE therapy. | |
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MedLine Citation:
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PMID: 22664098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Assessing the impact of therapeutic interventions on the clinical and immunologic responses of allergic subjects is a topic of extensive investigation. Available approaches include the measurement of in vivo allergen challenge responses, serologic measures, or in vitro studies of cells that participate in the allergic reaction. Several decades of work support that measures of allergen responses of IgE-bearing peripheral blood basophils can reflect clinical expression of allergic disease. In the last decade, an immune-based therapy targeting IgE, omalizumab, has emerged as an adjunct treatment for a variety of allergic diseases. This monoclonal humanized IgG antibody specifically binds circulating IgE at a region in the Fc tail that prevents IgE attachment to high affinity IgE receptor (FcεRI) bearing cell types such as tissue mast cells and blood basophils. This review focuses on methods to monitor changes of basophil allergen reactivity with a focus on omalizumab therapy and the implications for clinical disease management. |
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Authors:
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Sarbjit S Saini; Donald W MacGlashan |
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Publication Detail:
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Type: Journal Article; Review Date: 2012-06-01 |
Journal Detail:
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Title: Journal of immunological methods Volume: 383 ISSN: 1872-7905 ISO Abbreviation: J. Immunol. Methods Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-03 Completed Date: 2012-10-12 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 1305440 Medline TA: J Immunol Methods Country: Netherlands |
Other Details:
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Languages: eng Pagination: 60-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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John Hopkin's University, School of Medicine, USA. ssaini@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Anti-Idiotypic
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therapeutic use* Antibodies, Monoclonal, Humanized / therapeutic use* Basophils / immunology* Humans Hypersensitivity / blood, immunology, therapy* Immunoglobulin E / blood, immunology* Immunologic Tests* Immunotherapy / methods* Monitoring, Immunologic / methods* Predictive Value of Tests Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic; 0/Antibodies, Monoclonal, Humanized; 0/omalizumab; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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