Document Detail


Assessing Normal Growth of Hepatic Hemangiomas During Long-term Follow-up.
MedLine Citation:
PMID:  25321079     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Importance: Few long-term data describe the natural history of hepatic hemangiomas. Because these lesions are frequently imaged repetitively on studies performed for other indications, health care professionals are commonly confronted with the problem of a growing hemangioma. Because the rate and magnitude of normal growth is not well characterized, it is difficult to recognize lesions growing at an abnormal rate, which may require further evaluation or intervention.
Objectives: To establish quantitatively the expected growth rate of hepatic hemangiomas and to define a measure of hemangioma growth that could be used clinically to help identify hemangiomas for which growth is more than expected.
Design, Setting, and Participants: Retrospective cohort study at an academic hospital tertiary referral center evaluating the growth rate of hepatic hemangiomas on cross-sectional imaging studies during a 10-year period (1997-2007). The mean (SD) follow-up time was 3.7 (1.9) years. The radiology information system was searched in a 10-year period for hemangioma. Patients with hepatic hemangiomas that were 1 cm or larger as seen on cross-sectional imaging (computed tomography or magnetic resonance imaging), and 1 year or more apart were selected. Images with the longest interval between studies were selected for further review. Each study was rereviewed for diagnostic confirmation and to ensure consistency in measurement technique. Lesions were remeasured in 3 dimensions, and volumes were calculated using 3-dimensional software.
Main Outcomes and Measures: Primary outcomes include the fraction of hepatic hemangiomas that demonstrated growth during long-term follow-up and the annual growth rate of those lesions.
Results: A total of 163 hemangiomas were identified in 123 patients. The mean (SD) initial size was 3.2 (3.1) cm. During follow-up, 39.3% of hemangiomas grew 5% or more in mean linear dimension. The mean (SD) annual linear growth rate was 0.03 (0.21) cm for all lesions and 0.19 (0.23) cm for those that grew 5% or more. By volume, 44.7% of lesions grew 5% or more. The mean (SD) annual volumetric growth rate was 2.8% (21.0%) for all lesions and 17.7% (22.8%) in those that grew 5% or more. The initial size predicted the growth in linear dimension and volume (P < .001). There was no significant change in growth rate over time, indicating uniform growth (R = 0.00843; P = .92).
Conclusions and Relevance: Nearly 40% of hepatic hemangiomas grow over time. Although the overall rate of growth is slow, hemangiomas that exhibit growth do so at a modest rate (2 mm/y in linear dimension and 17.4% per year in volume). Further research is needed to determine how patients with more rapidly growing hemangiomas should be treated.
Authors:
Hani Y Hasan; J Louis Hinshaw; Edward J Borman; Alison Gegios; Glen Leverson; Emily R Winslow
Related Documents :
25211179 - Routine magnetic resonance imaging for idiopathic olfactory loss: a modeling-based econ...
24557639 - Deep pelvic endometriosis: don't forget round ligaments. review of anatomy, clinical ch...
24724049 - Pet/ct planning during chemoradiotherapy for esophageal cancer.
25467229 - Quantitative and qualitative comparison of 0.025mmol/kg gadobenate dimeglumine for abdo...
22941569 - Transient lateral patellar dislocation: review of imaging findings, patellofemoral anat...
22961189 - Vascular myelopathies.
8352859 - Mri in neonatal dural sinus thrombosis.
3484839 - Conventional radionuclide brain imaging in the era of transmission and emission tomogra...
25433369 - Comparison between the cranial magnetic resonance imaging features of neuromyelitis opt...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-15
Journal Detail:
Title:  JAMA surgery     Volume:  -     ISSN:  2168-6262     ISO Abbreviation:  JAMA Surg     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-16     Completed Date:  -     Revised Date:  2014-10-17    
Medline Journal Info:
Nlm Unique ID:  101589553     Medline TA:  JAMA Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Recent developments in out-of-plane metallocorrole chemistry across the periodic table.
Next Document:  TiO2@CeOx Core-Shell Nanoparticles as Artificial Enzymes with Peroxidase-Like Activity.