Document Detail

Assessing chronological aging in Saccharomyces cerevisiae.
MedLine Citation:
PMID:  23296677     Owner:  NLM     Status:  MEDLINE    
Saccharomyces cerevisiae is one of the most studied model organisms for the identification of genes and mechanisms that affect aging. The chronological lifespan (CLS) assay, which monitors the survival of a non-dividing population, is one of the two methods to study aging in yeast. To eliminate potential artifacts and identify genes and signaling pathways that may also affect aging in higher eukaryotes, it is important to determine CLS by multiple methods. Here, we describe these methods as well as the assays to study macromolecular damage during aging in yeast, with a focus on genomic instability.
Jia Hu; Min Wei; Mario G Mirisola; Valter D Longo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  965     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-06-13     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  463-72     Citation Subset:  IM    
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MeSH Terms
Cell Nucleus / genetics
Culture Media / chemistry
DNA, Fungal / genetics
Genomic Instability
Mutation Rate
Saccharomyces cerevisiae / cytology,  genetics*,  growth & development*
Time Factors
Water / chemistry
Grant Support
Reg. No./Substance:
0/Culture Media; 0/DNA, Fungal; 059QF0KO0R/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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