Document Detail


Assessing Cell Size and Cell Cycle Regulation in Cells with Altered TOR Activity.
MedLine Citation:
PMID:  22125068     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Target of rapamycin (TOR) regulates the growth of cells and organisms. Numerous growth-promoting and growth-arresting pathways converge on TOR; TOR acts as an important hub, balancing the pro- and anti-growth signals within a cell. Since it regulates growth at the cellular level, cell size can be used as an indirect readout of TOR activity. Here, we describe methods used to analyze cell size in cell culture and in the Drosophila wing.
Authors:
Megan Cully; Julian Downward
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  821     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2012  
Date Detail:
Created Date:  2011-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-37     Citation Subset:  IM    
Affiliation:
Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, UK.
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