| Assessing Cell Size and Cell Cycle Regulation in Cells with Altered TOR Activity. | |
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MedLine Citation:
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PMID: 22125068 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Target of rapamycin (TOR) regulates the growth of cells and organisms. Numerous growth-promoting and growth-arresting pathways converge on TOR; TOR acts as an important hub, balancing the pro- and anti-growth signals within a cell. Since it regulates growth at the cellular level, cell size can be used as an indirect readout of TOR activity. Here, we describe methods used to analyze cell size in cell culture and in the Drosophila wing. |
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Authors:
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Megan Cully; Julian Downward |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 821 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2012 |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 227-37 Citation Subset: IM |
Affiliation:
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Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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