| Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media. | |
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MedLine Citation:
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PMID: 18062672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glycoconjugates can be artificially synthesized by combinatorial biocatalysis. An example is given in this paper describing the construction of glycoconjugates array by using glycosidase and lipase in nonaqueous media. This array was started from glucose, with three aryl alcohols as the aglycone moiety of glycosides and five acids or esters as acyl donors for combinatorial acylation of glycosides, affording a three-dimensional array containing about 30 members with diverse structures. The array would be more abundant if more aglycones and acyl donors with other structures were filled in. Indeed, diverse classes of carbohydrates besides glucose can also be employed for generating diverse glycoconjugates due to their different roles in numerous physiological responses. The composition and distribution of the demonstration glycoconjugates array was detected and evaluated by HPLC-MS with electrospray ionization. And also, the distribution of the artificial array can be adjusted by changing the molar ratio of the auxiliary materials. |
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Authors:
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Hui-Lei Yu; Jian-He Xu; Yu-Xiao Wang; Wen-Ya Lu; Guo-Qiang Lin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-07 |
Journal Detail:
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Title: Journal of combinatorial chemistry Volume: 10 ISSN: 1520-4774 ISO Abbreviation: J Comb Chem Publication Date: 2008 Jan-Feb |
Date Detail:
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Created Date: 2008-01-14 Completed Date: 2008-02-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886263 Medline TA: J Comb Chem Country: United States |
Other Details:
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Languages: eng Pagination: 79-87 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, P.R. China. jianhexu@ecust.edu.cn |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acylation Catalysis Chromatography, High Pressure Liquid Combinatorial Chemistry Techniques / methods* Glycoconjugates / chemical synthesis*, chemistry Glycoside Hydrolases / chemistry* Glycosides / chemistry* Lipase / chemistry* Models, Molecular Molecular Structure |
| Chemical | |
Reg. No./Substance:
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0/Glycoconjugates; 0/Glycosides; EC 3.1.1.3/Lipase; EC 3.2.1.-/Glycoside Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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