Document Detail


Assembly and persistence of primary cilia in dividing Drosophila spermatocytes.
MedLine Citation:
PMID:  22898783     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Basal bodies are freed from cilia and transition into centrioles to organize centrosomes in dividing cells. A mutually exclusive centriole/basal body existence during cell-cycle progression has become a widely accepted principle. Contrary to this view, we show here that cilia assemble and persist through two meiotic divisions in Drosophila spermatocytes. Remarkably, all four centrioles assemble primary cilia-centriole complexes that transit from the plasma membrane encased in a packet of membrane, recruit centrosomal material into microtubule-organizing centers, and persist at the spindle poles through division. Thus, spermatocyte centrioles organize centrosomes and cilia simultaneously at cell division. These findings challenge the prevailing view that cilia antagonize cell-cycle progression and raise the possibility that cilium retention at cell division may occur in diverse organisms and cell types.
Authors:
Maria Giovanna Riparbelli; Giuliano Callaini; Timothy L Megraw
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental cell     Volume:  23     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-17     Completed Date:  2012-11-01     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  425-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Evolutionary Biology, University of Siena, Via A. Moro 4, 53100 Siena, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division*
Cilia
Drosophila melanogaster / cytology*
Male
Microscopy, Electron, Transmission
Spermatocytes / cytology*
Grant Support
ID/Acronym/Agency:
GM068756/GM/NIGMS NIH HHS; R01 GM068756/GM/NIGMS NIH HHS
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