Document Detail


Assembly and patterning of the vascular network of the vertebrate hindbrain.
MedLine Citation:
PMID:  21429985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cranial vasculature is essential for the survival and development of the central nervous system and is important in stroke and other brain pathologies. Cranial vessels form in a reproducible and evolutionarily conserved manner, but the process by which these vessels assemble and acquire their stereotypic patterning remains unclear. Here, we examine the stepwise assembly and patterning of the vascular network of the zebrafish hindbrain. The major artery supplying the hindbrain, the basilar artery, runs along the ventral keel of the hindbrain in all vertebrates. We show that this artery forms by a novel process of medial sprouting and migration of endothelial cells from a bilateral pair of primitive veins, the primordial hindbrain channels. Subsequently, a second wave of dorsal sprouting from the primordial hindbrain channels gives rise to angiogenic central arteries that penetrate into and innervate the hindbrain. The chemokine receptor cxcr4a is expressed in migrating endothelial cells of the primordial hindbrain channels, whereas its ligand cxcl12b is expressed in the hindbrain neural keel immediately adjacent to the assembling basilar artery. Knockdown of either cxcl12b or cxcr4a results in defects in basilar artery formation, showing that the assembly and patterning of this crucial artery depends on chemokine signaling.
Authors:
Misato Fujita; Young R Cha; Van N Pham; Atsuko Sakurai; Beth L Roman; J Silvio Gutkind; Brant M Weinstein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2011-03-23
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  138     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-13     Completed Date:  2011-07-01     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  1705-15     Citation Subset:  IM    
Affiliation:
Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Arteries / embryology,  metabolism,  physiology
Blood Vessels / embryology*,  metabolism
Body Patterning / genetics,  physiology*
Cells, Cultured
Embryo, Nonmammalian
Green Fluorescent Proteins / genetics,  metabolism
Humans
Models, Biological
Neovascularization, Physiologic / genetics,  physiology
Rhombencephalon / blood supply*,  embryology*,  metabolism
Troponin T / genetics,  metabolism
Vertebrates / embryology*,  genetics,  metabolism,  physiology
Zebrafish / embryology,  genetics,  physiology
Grant Support
ID/Acronym/Agency:
R01 HL079108-07/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Troponin T; 0/enhanced green fluorescent protein; 147336-22-9/Green Fluorescent Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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