Document Detail


Assembly dynamics of the bacterial MinCDE system and spatial regulation of the Z ring.
MedLine Citation:
PMID:  17328675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The positioning of a cytoskeletal element that dictates the division plane is a fundamental problem in biology. The assembly and positioning of this cytoskeletal element has to be coordinated with DNA segregation and cell growth to ensure that equal-sized progeny cells are produced, each with a copy of the chromosome. In most prokaryotes, cytokinesis involves positioning a Z ring assembled from FtsZ, the ancestral homologue of tubulin. The position of the Z ring is determined by a gradient of negative regulators of Z-ring assembly. In Escherichia coli, the Min system consists of three proteins that cooperate to position the Z ring through a fascinating oscillation, which inhibits the formation of the Z ring away from midcell. Additional gradients of negative regulators of FtsZ assembly are used by E. coli and other bacteria to achieve spatial control of Z-ring assembly.
Authors:
Joe Lutkenhaus
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of biochemistry     Volume:  76     ISSN:  0066-4154     ISO Abbreviation:  Annu. Rev. Biochem.     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-20     Completed Date:  2007-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985150R     Medline TA:  Annu Rev Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-62     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. jlutkenh@kumc.edu
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphatases / genetics,  metabolism*
Bacteria* / cytology,  metabolism
Bacterial Proteins / genetics,  metabolism*
Cell Cycle Proteins / genetics,  metabolism*
Cell Membrane / metabolism
Cytokinesis / physiology*
Cytoskeleton / metabolism*
Escherichia coli Proteins / genetics,  metabolism*
Gene Expression Regulation, Bacterial
Phenotype
Protein Binding
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Cell Cycle Proteins; 0/Escherichia coli Proteins; 0/MinC protein, Bacteria; 0/MinE protein, E coli; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/MinD protein, E coli

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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