| Assays for inverse agonists in the visual system. | |
| | |
MedLine Citation:
|
PMID: 21050919 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Visual pigment proteins belong to the superfamily of G protein-coupled receptors and are the light-sensitive molecules in rod and cone photoreceptor cells. The protein moiety is known as opsin and the ligand in the dark is 11-cis retinal, which serves as both the photon detector and an inverse agonist. While much is known about properties of the rod pigment rhodopsin, much less is understood about cone visual pigments. Being able to identify ligands that effect opsins give an insight into structure-activity relationships. The action of some ligands indicates that there are differences between not only rod and cone opsins but also among the different classes of cone opsins. Furthermore, inverse agonists of cone opsins may have potential therapeutic uses under conditions when the native 11-cis retinal ligand is absent. A method for determining the effects of ligands on rod and cone opsin activity is described. |
| | |
Authors:
|
Masahiro Kono |
Related Documents
:
|
8529019 - Molecular basis for tetrachromatic color vision. 6642929 - Visual acuity and cone spatial density in retinitis pigmentosa. 11511659 - Cone-based vision of rats for ultraviolet and visible lights. 16377059 - The simple perfection of quantum correlation in human vision. 2781729 - Rods trigger light adaptive retinomotor movements in all spectral cone types of a teleo... 20430049 - Psychophysical channels and erp population responses in human visual cortex: area summa... 15883809 - Trajectory of contact region on the fingerpad gives the illusion of haptic shape. 12789959 - Clinical evaluation of a 35% hydrogen peroxide in-office whitening system. 15704409 - Arrival-time structure of the time-averaged ambient noise cross-correlation function in... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Methods in enzymology Volume: 485 ISSN: 1557-7988 ISO Abbreviation: Meth. Enzymol. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0212271 Medline TA: Methods Enzymol Country: United States |
Other Details:
|
Languages: eng Pagination: 213-24 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
R01-EY019515/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: ?-Aminobutyric acid type A (GABA(A)) receptor subtype inverse agonists as therapeutic agents in cogn...
Next Document: Receptor-driven identification of novel human A? adenosine receptor antagonists as potential therape...