Document Detail

Assay for uric acid level in rat striatum by a reagentless biosensor based on functionalized multi-wall carbon nanotubes with tin oxide.
MedLine Citation:
PMID:  15977031     Owner:  NLM     Status:  MEDLINE    
A novel reagentless amperometric uric acid biosensor based on functionalized multi-wall carbon nanotubes (MWCNTs) with tin oxide (SnO2) nanoparticles has been developed. This was successfully applied to assay uric acid levels from an in vivo microdialysis sampling. Compared with unfunctionalized or traditional carboxylic acid (-COOH)-functionalized MWCNTs, the MWCNTs-SnO2 electrode exhibited higher electrocatalytic oxidation to uric acid. Here, MWCNTs-SnO2 may act as an efficient promoter, and the system exhibited a linear dependence on the uric acid concentration over the range from 1.0 x 10(-7) to 5.0 x 10(-4) mol L(-1). In addition, there was little ascorbic acid interference. The high sensitivity of the MWCNTs-SnO2 modified enzyme electrode enabled the monitoring of trace levels of uric acid in dialysate samples in rat striatum.
Fen-Fen Zhang; Xiao-Li Wang; Chen-Xin Li; Xiao-Hua Li; Qiao Wan; Yue-Zhong Xian; Li-Tong Jin; Katsunobu Yamamoto
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-24
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  382     ISSN:  1618-2642     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-18     Completed Date:  2007-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1368-73     Citation Subset:  IM    
Department of Chemistry, East China Normal University, Shanghai 200062, China.
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MeSH Terms
Biosensing Techniques / methods*
Corpus Striatum / chemistry*
Microscopy, Electron, Transmission
Nanotubes, Carbon / chemistry*,  ultrastructure
Rats, Sprague-Dawley
Spectroscopy, Fourier Transform Infrared
Tin Compounds / chemistry*
Urate Oxidase / chemistry*
Uric Acid / analysis*
Reg. No./Substance:
0/Nanotubes, Carbon; 0/Tin Compounds; 18282-10-5/stannic oxide; 69-93-2/Uric Acid; EC Oxidase

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