| Assay for uric acid level in rat striatum by a reagentless biosensor based on functionalized multi-wall carbon nanotubes with tin oxide. | |
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MedLine Citation:
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PMID: 15977031 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel reagentless amperometric uric acid biosensor based on functionalized multi-wall carbon nanotubes (MWCNTs) with tin oxide (SnO2) nanoparticles has been developed. This was successfully applied to assay uric acid levels from an in vivo microdialysis sampling. Compared with unfunctionalized or traditional carboxylic acid (-COOH)-functionalized MWCNTs, the MWCNTs-SnO2 electrode exhibited higher electrocatalytic oxidation to uric acid. Here, MWCNTs-SnO2 may act as an efficient promoter, and the system exhibited a linear dependence on the uric acid concentration over the range from 1.0 x 10(-7) to 5.0 x 10(-4) mol L(-1). In addition, there was little ascorbic acid interference. The high sensitivity of the MWCNTs-SnO2 modified enzyme electrode enabled the monitoring of trace levels of uric acid in dialysate samples in rat striatum. |
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Authors:
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Fen-Fen Zhang; Xiao-Li Wang; Chen-Xin Li; Xiao-Hua Li; Qiao Wan; Yue-Zhong Xian; Li-Tong Jin; Katsunobu Yamamoto |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-06-24 |
Journal Detail:
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Title: Analytical and bioanalytical chemistry Volume: 382 ISSN: 1618-2642 ISO Abbreviation: Anal Bioanal Chem Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-18 Completed Date: 2007-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101134327 Medline TA: Anal Bioanal Chem Country: Germany |
Other Details:
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Languages: eng Pagination: 1368-73 Citation Subset: IM |
Affiliation:
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Department of Chemistry, East China Normal University, Shanghai 200062, China. fenfenzhang@yahoo.com.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biosensing Techniques / methods* Corpus Striatum / chemistry* Electrochemistry Male Microscopy, Electron, Transmission Nanotubes, Carbon / chemistry*, ultrastructure Rats Rats, Sprague-Dawley Spectroscopy, Fourier Transform Infrared Tin Compounds / chemistry* Urate Oxidase / chemistry* Uric Acid / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Nanotubes, Carbon; 0/Tin Compounds; 18282-10-5/stannic oxide; 69-93-2/Uric Acid; EC 1.7.3.3/Urate Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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