Document Detail

Assay of bone resorption in vivo with 3H-tetracycline.
MedLine Citation:
PMID:  953784     Owner:  NLM     Status:  MEDLINE    
3H-Tetracycline (3H-TC) was used to quantify resorption in whole bones of growing rats and dogs. After repeated isotopic labeling of actively growing embryos or neonates, 3H-TC was observed to be distributed homogeneously and in equilibrium with 45Ca. A rapid and large loss of 3H-TC and a small loss of 45Ca occurred during the early weeks of rapid bone growth, suggesting that absolute amounts of 45Ca resorbed from bone, as reflected by losses of 3H-TC, are five to ten times greater than the net amounts of 45Ca lost from bone. Minimal loss of 3H-TC occurred due to nonspecific physicochemical exchange in vivo or in vitro (5%) except with nonradioactive tetracycline, and 3H-TC was not greatly exchanged or reused (10%) in vivo. The data are considered in terms of local and systemic conservation of calcium.
L Klein; K V Jackman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Calcified tissue research     Volume:  20     ISSN:  0008-0594     ISO Abbreviation:  Calcif Tissue Res     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-11-01     Completed Date:  1976-11-01     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0114414     Medline TA:  Calcif Tissue Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  275-90     Citation Subset:  IM    
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MeSH Terms
Bone Development
Bone Resorption / diagnosis*
Calcium / metabolism
Calcium Radioisotopes
Isotope Labeling
Tetracycline / diagnostic use*
Reg. No./Substance:
0/Calcium Radioisotopes; 10028-17-8/Tritium; 60-54-8/Tetracycline; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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