Document Detail

Aspirin toxicity in chicks given diets deficient in linoleic acid.
MedLine Citation:
PMID:  7972284     Owner:  NLM     Status:  MEDLINE    
The toxicity of dietary aspirin on growth rate and lipid metabolism was investigated under linoleic acid (LA; 18: 2n-6) deficient conditions. One-week-old chicks were given diets containing 0 or 2% LA with or without 0.4% aspirin, until 4 weeks of age. Growth was severely depressed by dietary aspirin when chicks were given the LA-free diet. The liver was enlarged by both the aspirin and LA deficiency. The aspirin treatment induced a significant increase of 18:0 and arachidonic acid (20: 4n-6) and a decrease of 18: 1n-9 in the liver. In chicks fed LA-free diets, the ratio of 20:3n-9/20: 4n-6, which was used as an indicator of LA deficiency, was suppressed by aspirin treatment. In conclusion, the present results suggest that aspirin toxicity is altered by dietary LA concentrations.
A Murai; M Furuse; J Okumura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  48     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-12-29     Completed Date:  1994-12-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1047-51     Citation Subset:  IM    
Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan.
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MeSH Terms
Aspirin / toxicity*
Cholesterol / blood
Eating / drug effects
Fatty Acids / metabolism
Growth / drug effects
Linoleic Acids / deficiency*
Lipid Metabolism
Liver / drug effects,  metabolism
Organ Size / drug effects
Reg. No./Substance:
0/Fatty Acids; 0/Linoleic Acids; 50-78-2/Aspirin; 57-88-5/Cholesterol

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