Document Detail

Aspirin therapy in vernal conjunctivitis.
MedLine Citation:
PMID:  6573138     Owner:  NLM     Status:  MEDLINE    
Prostaglandin D2 is a secondary mast cell mediator that causes redness, chemosis, mucous discharge, and eosinophil chemotaxis in the eye. It may play an important role in allergic ocular disease. Although histamine is a key mediator of allergic inflammation, antihistamine therapy provides only symptomatic relief. We added aspirin therapy to the treatment regimen of three patients with vernal conjunctivitis. Aspirin acetylates the enzyme cyclooxygenase, thereby preventing the formation of prostaglandin D2. Within two weeks after initiation of aspirin therapy, we noted dramatic improvement in conjunctival and episcleral redness and resolution of keratitis and limbal infiltration. We recommend a trial of oral aspirin as adjunctive therapy for intractable cases of vernal conjunctivitis.
M B Abelson; S I Butrus; J H Weston
Related Documents :
16898578 - Treatment of hypertriglyceridemia.
6573138 - Aspirin therapy in vernal conjunctivitis.
1792658 - Prostanoids in therapy of peripheral arterial occlusive disease.
23353558 - Measurement of tactile allodynia in a murine model of bacterial prostatitis.
12676038 - Trigger point--acupuncture point correlations revisited.
21631408 - Control of neuropathic pain by immune cells and opioids.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  95     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  502-5     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aspirin / therapeutic use*
Conjunctivitis / drug therapy*
Histamine / physiology
Hypersensitivity / complications*
Mast Cells / physiology
Prostaglandin D2
Prostaglandins D / physiology
Urticaria Pigmentosa / drug therapy
Reg. No./Substance:
0/Prostaglandins D; 41598-07-6/Prostaglandin D2; 50-78-2/Aspirin; 51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Search for a red cell enzyme or serum protein marker in amyotrophic lateral sclerosis and parkinsoni...
Next Document:  Orthodontic management of mandibular canine-incisor transposition.