Document Detail

Aspirin sensitivity and urticaria.
MedLine Citation:
PMID:  12653694     Owner:  NLM     Status:  MEDLINE    
The relationship of aspirin sensitivity to urticaria is complex. Aspirin sensitivity can cause acute urticaria in some individuals, aggravate pre-existing chronic urticaria in others or, rarely, act as a cofactor with food or exercise to provoke anaphylaxis. Individuals who react with urticaria appear to come from a different population to those who react with asthma, although there is some overlap. Aspirin-sensitive chronic urticaria patients may also react adversely to some food additives. The pharmacological mechanisms of aspirin-sensitive urticaria are not fully understood but probably involve diversion of arachidonic acid metabolism from prostaglandin to cysteinyl leukotriene formation leading to direct effects on blood vessels and delayed mast cell degranulation with release of histamine. Cross-reactivity amongst all nonsteroidal drugs is common in aspirin-aggravated chronic urticaria but appears not to occur with selective cyclo-oxygenase 2 inhibitors.
C E H Grattan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  28     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-25     Completed Date:  2003-05-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-7     Citation Subset:  IM    
Dermatology Centre, Norfolk and Norwich University Hospital, Norwich, UK.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Aspirin / adverse effects*
Asthma / complications
Drug Eruptions / drug therapy,  etiology*
Food-Drug Interactions / physiology
Urticaria / chemically induced*,  complications,  drug therapy
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 50-78-2/Aspirin

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