Document Detail


Aspirin sensitivity and urticaria.
MedLine Citation:
PMID:  12653694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship of aspirin sensitivity to urticaria is complex. Aspirin sensitivity can cause acute urticaria in some individuals, aggravate pre-existing chronic urticaria in others or, rarely, act as a cofactor with food or exercise to provoke anaphylaxis. Individuals who react with urticaria appear to come from a different population to those who react with asthma, although there is some overlap. Aspirin-sensitive chronic urticaria patients may also react adversely to some food additives. The pharmacological mechanisms of aspirin-sensitive urticaria are not fully understood but probably involve diversion of arachidonic acid metabolism from prostaglandin to cysteinyl leukotriene formation leading to direct effects on blood vessels and delayed mast cell degranulation with release of histamine. Cross-reactivity amongst all nonsteroidal drugs is common in aspirin-aggravated chronic urticaria but appears not to occur with selective cyclo-oxygenase 2 inhibitors.
Authors:
C E H Grattan
Related Documents :
21507854 - Regulation of compounding by the food and drug administration: a tale of 2 circuits.
11146694 - Anaphylaxis in the united states: an investigation into its epidemiology.
10945744 - Sensitizing capacity of 5,5'-di-tert-butyl-2,2'-dihydorxy-(hydroxymethyl)-dibenzyl ethe...
9820394 - Are adverse food reactions linked to irritable bowel syndrome?
6363234 - A probable case of euthanasia amongst prehistoric aborigines at roonka, south australia.
12945754 - Phenotypic plasticity of reproductive effort in a colonial ascidian, botryllus schlosseri.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  28     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-25     Completed Date:  2003-05-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-7     Citation Subset:  IM    
Affiliation:
Dermatology Centre, Norfolk and Norwich University Hospital, Norwich, UK. clive.grattan@nnuh.nhs.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Aspirin / adverse effects*
Asthma / complications
Drug Eruptions / drug therapy,  etiology*
Food-Drug Interactions / physiology
Humans
Urticaria / chemically induced*,  complications,  drug therapy
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dissociation of augmented physiological, hormonal and cognitive responses to hypoglycaemia with sust...
Next Document:  Lichen sclerosus.