| Aspirin sensitivity: the role for aspirin challenge and desensitization in postmyocardial infarction patients. | |
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MedLine Citation:
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PMID: 10393393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aspirin is one of the world's most commonly used medications and its use benefits many diverse conditions. Adverse reactions, however, are relatively common as well. Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction. We report 3 cases in whom aspirin was indicated for secondary prophylaxis of myocardial infarction but in whom a remote history of an untoward reaction to it prevented its initial use. These patients all underwent further evaluation of their pulmonary and allergic history and all 3 were challenged with aspirin. Two patients were found not to be sensitive and started on aspirin, the other had a classic asthmatic reaction to the drug and was successfully desensitized to aspirin allowing for its use. |
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Authors:
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O P Schaefer; J M Gore |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cardiology Volume: 91 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 1999 |
Date Detail:
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Created Date: 2000-01-04 Completed Date: 2000-01-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 8-13 Citation Subset: IM |
Affiliation:
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Division of Pulmonary, Allergy and Critical Care Medicine, University of Massachusetts Medical School, Worcester, Mass., USA. oren.schaefer@banyan.ummed.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aspirin / administration & dosage, adverse effects*, diagnostic use Asthma / chemically induced, diagnosis, immunology Desensitization, Immunologic* Diagnosis, Differential Dose-Response Relationship, Drug Drug Eruptions / diagnosis, immunology, therapy Drug Hypersensitivity / diagnosis, immunology, therapy* Female Humans Male Middle Aged Myocardial Infarction / drug therapy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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