Document Detail


Aspirin sensitivity does not compromise quality of life outcomes in patients with Samter's triad.
MedLine Citation:
PMID:  23712910     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To demonstrate that quality-of-life outcomes after endoscopic sinus surgery are not compromised in patients with Samter's triad (asthma, nasal polyps, aspirin sensitivity) when compared to patients with eosinophilic chronic rhinosinusitis with nasal polyposis (eCRSwP) who are not aspirin sensitive. STUDY DESIGN: Retrospective review of prospectively-collected data METHODS: Thirty-two patients with Samter's triad were identified from a prospectively-collected patient database from 2003 to 2012. Preoperative and postoperative symptom and endoscopy scores were compared to those of thirty-seven consecutive patients with eCRSwP who were not aspirin sensitive (control). Student's t-test and Fisher's exact test were used to examine for differences between the two groups. Symptom scores were assessed using the SNOT-20 outcomes instrument. Endoscopy findings were scored according to the Lund-Kennedy methodology. RESULTS: Samter's triad patients had significantly worse disease preoperatively when compared to the control group: SNOT-20 (31.1 vs. 22.1, p=0.004), endoscopy score (10.9 vs. 7.6, p=0.0005), and Lund-Mackay CT score (18.9 vs. 13.9, p=0.0001). Although postoperative endoscopy scores remained worse in the Samter's triad group, postoperative SNOT-20 scores were comparable to those of the control group at ≥ 3 years follow-up (22.8 vs. 17.3, p=0.43). CONCLUSION: Although Samter's triad patients present with more severe disease and are more likely to undergo revision surgery, they have postoperative quality-of-life outcomes that are comparable to patients with eCRSwP who are not aspirin sensitive. This is the first study to utilize a disease-specific, validated outcomes instrument in comparing Samter's triad patients with aspirin tolerant patients who have nasal polyposis and tissue eosinophilia.
Authors:
David W Jang; Brett T Comer; Vasileios Lachanas; Stilianos E Kountakis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-27
Journal Detail:
Title:  The Laryngoscope     Volume:  -     ISSN:  1531-4995     ISO Abbreviation:  Laryngoscope     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 The American Laryngological, Rhinological, and Otological Society, Inc.
Affiliation:
Department of Otolaryngology-Head & Neck Surgery, Georgia Regents University.
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