Document Detail

Aspirin resistance in cardiovascular disease: a review.
MedLine Citation:
PMID:  15079767     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Aspirin is effective at reducing the cardiovascular event rate in defined patient groups. The introduction of antiplatelet therapies other than aspirin and the concept of aspirin resistance have led to critical reappraisal of current treatment. This review aims to clarify the evidence for aspirin resistance in patients with atherosclerosis. METHODS: Medline search was performed to identify publications concerned with antiplatelet effects of aspirin and failure of aspirin therapy. Manual cross referencing was also performed. RESULTS AND CONCLUSION: Wide variations in the rate of aspirin resistance (5.5-75%) have been reported. The lack of consensus on an appropriate definition and the number of different tests used to investigate aspirin resistance needs to be addressed. There are few studies where the primary aim was to document aspirin resistance or aspirin non-response. Further work should aim to investigate if aspirin resistance is clinically important and, if it is, what treatments may be beneficial to the at risk patient.
S Wong; M Appleberg; C M Ward; D R Lewis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  27     ISSN:  1078-5884     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-13     Completed Date:  2004-06-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  456-65     Citation Subset:  IM    
Department of Vascular Surgery, The Royal North Shore Hospital, St Leonard's, Sydney, NSW 2065, Australia.
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MeSH Terms
Arteriosclerosis / prevention & control*
Aspirin / administration & dosage,  pharmacology*,  therapeutic use
Drug Resistance
Platelet Aggregation Inhibitors / administration & dosage,  pharmacology*,  therapeutic use
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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