| Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. | |
| | |
MedLine Citation:
|
PMID: 20886344 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND AND AIMS: Aspirin is associated with a reduced risk of colorectal cancer (CRC), and it showed inhibited effects on interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway which is thought to play an important role in intestinal inflammation and the tumorigenesis of CRC. METHODS: Mouse model for inflammation-related CRC was induced by a combined treatment with azoxymethane (AOM) and dextran sodium sulfate (DSS) in BALB/c mice. Effects of aspirin on tumor number and size and apoptosis of CRC cells were investigated. Key molecules of IL-6-STAT3 pathway, such as IL-6, sIL-6R, phosphorylated STAT3, and their downstream anti-apoptotic genes Bcl-2 and Bcl-xl, were assessed by ELISA and Western blot. RESULTS: Treatment with aspirin significantly promoted CRC cell apoptosis in AOM/DSS-induced CRC mice in vivo. The expression level of IL-6, which is an upstream molecule of STAT3 and capable of activating STAT3, was reduced in aspirin-treated mice. Furthermore, the phosphorylated form of STAT3 and the levels of STAT3's target gene products such as Bcl-xl and Bcl-2, which are essential for cell growth and survival, were also decreased in aspirin-treated mice. CONCLUSIONS: Our data suggested that the protective mechanisms of aspirin in CRC may be associated with its effects on induction of CRC cell apoptosis and suppression of IL-6-STAT3 signaling pathway, which implied that aspirin has a potential therapeutic activity in CRC. |
| | |
Authors:
|
Yun Tian; Ying Ye; Wei Gao; Hong Chen; Ting Song; Daqing Wang; Xiaoyun Mao; Changshan Ren |
Related Documents
:
|
12507784 - Expression ratios of the bcl-2 family proteins and disease activity in multiple sclerosis. 20889974 - Parkin mono-ubiquitinates bcl-2 and regulates autophagy. 18830594 - Zebularine suppresses the apoptotic potential of 5-fluorouracil via camp/pka/creb pathw... 9694974 - Delta9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: involveme... 8099694 - The action of beta-receptors on microvascular endothelium or: is airways plasma exudati... 11715214 - Mediator antagonists in the treatment of allergic disease. |
Publication Detail:
|
Type: Journal Article Date: 2010-10-01 |
Journal Detail:
|
Title: International journal of colorectal disease Volume: 26 ISSN: 1432-1262 ISO Abbreviation: Int J Colorectal Dis Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8607899 Medline TA: Int J Colorectal Dis Country: Germany |
Other Details:
|
Languages: eng Pagination: 13-22 Citation Subset: IM |
Affiliation:
|
Cancer Research Institute, the First Affiliated Hospital, China Medical University, Shenyang 110001, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anal region: an unusual location of granular cell tumour.
Next Document: Co-existence of three rare gynecological tumors in a 79-year-old woman.