Document Detail

Aspirin ototoxicity in the guinea pig.
MedLine Citation:
PMID:  1169743     Owner:  NLM     Status:  MEDLINE    
Aspirin ototoxicity has been studied on guinea pigs by shiver-audiometry and histological investigation of the cochlear duct. One dose of 350 mg/kg has provoked, after 7 h, a mean hearing loss of 18-24 dB at 0.25-8 kHz, followed by complete recovery in 3 days. The difference between the administration of 50 mg/kg/day and 350 mg/kg/day consists of a wide extension of the frequencies involved, and in about 10 dB a greater hearing loss. In both cases, no appreciable recovery of hearing was observed after 22 days (the histological investigations were negative). The biochemical pathogenesis of aspirin ototoxicity is discussed and periodical audiometric controls before and during salicylate treatment are recommended.
S Crifò
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ORL; journal for oto-rhino-laryngology and its related specialties     Volume:  37     ISSN:  0301-1569     ISO Abbreviation:  ORL J. Otorhinolaryngol. Relat. Spec.     Publication Date:  1975  
Date Detail:
Created Date:  1975-08-20     Completed Date:  1975-08-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0334721     Medline TA:  ORL J Otorhinolaryngol Relat Spec     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  27-34     Citation Subset:  IM    
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MeSH Terms
Aspirin / administration & dosage,  toxicity*
Deafness / etiology
Differential Threshold
Dose-Response Relationship, Drug
Ear, Inner / drug effects*
Guinea Pigs
Hearing / drug effects*
Reflex / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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