| Aspirin and non-small cell lung cancer resections: effect on long-term survival. | |
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MedLine Citation:
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PMID: 20359903 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: Survival after resections for non-small cell lung cancer remains poor. Recurrent lung cancer remains common. Due to the common risk factor of smoking, cardiovascular deaths occur in the absence of recurrent lung cancer in up to 15% of patients. Aspirin has been proven to reduce cardiovascular mortality as a secondary prophylactic agent, but not as a primary agent. Aspirin being a COX-2 inhibitor has been shown to reduce the chance of metastasis in adenocarcinoma but not squamous carcinoma. We sought to investigate the effect of long-term aspirin therapy on survival post potentially curative surgery. METHODS: We analysed a prospective thoracic surgical database, from time period 2003 to date. Patients who were on aspirin pre-operatively, N=412 were compared to non users, N=1353. Patient long-term outcome was assessed utilising the national strategic tracking service that operates in the United Kingdom. Cox proportional hazards analysis was used to determine significant factors affecting survival. RESULTS: 100% survival follow up was achieved. Regular users of aspirin had >5% increased survival, which was significant, p=0.05, despite having a higher cardiovascular risk profile. Mode of death data was not available. CONCLUSIONS: Adjuvant aspirin post resection for potentially curative non-small cell lung cancer significantly increases survival. The mechanism of increased survival needs further investigation and is the basis for the trial: Adjuvant Aspirin for Non-Small cell Lung Cancer--The Big A Trial. www.TheBigATrial.co.uk. |
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Authors:
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Eustace Fontaine; James McShane; Richard Page; Michael Shackcloth; Neeraj Mediratta; Martyn Carr; Ajab Soorae; Michael Poullis |
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Publication Detail:
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Type: Journal Article Date: 2010-03-31 |
Journal Detail:
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Title: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Volume: 38 ISSN: 1873-734X ISO Abbreviation: Eur J Cardiothorac Surg Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804069 Medline TA: Eur J Cardiothorac Surg Country: Germany |
Other Details:
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Languages: eng Pagination: 21-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool, L14 3PE England, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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