Document Detail


Aspirin metabolites causing misinterpretation of paracetamol results.
MedLine Citation:
PMID:  6517496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inadequacy of single, simple arithmetic corrections for salicylate interference in the widely employed Glynn and Kendal technique for plasma paracetamol assay is highlighted by reference to an actual case of combined salicylate/paracetamol intoxication in an infant. Attention is drawn for the first time to the not insubstantial contribution to such interference made by even the minor metabolites of salicylate. The conclusion is reached that is necessary, particularly in the assessment of paracetamol toxicity, to determine the presence of salicylate, and when present, to employ a specific method for the estimation of paracetamol.
Authors:
N R Badcock; A C Penna; D S Everett; L N Sansom
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  21 ( Pt 6)     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-02-15     Completed Date:  1985-02-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  527-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / blood*,  poisoning
Aspirin / blood*
Biotransformation
Chromatography, High Pressure Liquid / methods
Gentisates*
Humans
Hydroxybenzoic Acids / blood
Infant
Male
Salicylic Acid
Salicylic Acids / poisoning
Chemical
Reg. No./Substance:
0/Gentisates; 0/Hydroxybenzoic Acids; 0/Salicylic Acids; 103-90-2/Acetaminophen; 490-79-9/2,5-dihydroxybenzoic acid; 50-78-2/Aspirin; 69-72-7/Salicylic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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