Document Detail

Aspirin lowers blood pressure in patients with renovascular hypertension.
MedLine Citation:
PMID:  2680959     Owner:  NLM     Status:  MEDLINE    
To clarify the role of renal prostanoid in hyperreninemia and high blood pressure in human renovascular hypertension, we measured prostaglandin E2 and renin activity in renal venous and abdominal aortic plasma before and after the intravenous administration of the cyclooxygenase inhibitor, aspirin DL-lysine. Subjects were six patients with unilateral renovascular hypertension and six with essential hypertension. In patients with renovascular hypertension, prostaglandin E2 concentration in renal venous plasma from the stenotic kidney was 9.25 +/- 1.48 pg/ml, which was significantly higher (p less than 0.01) than the concentration in the renal venous plasma from the normal kidney (4.97 +/- 1.02 pg/ml) or in the aortic plasma (2.59 +/- 0.15 pg/ml). Plasma renin activity was also higher in the renal vein of the stenotic kidney than in the other two sites. The stenotic side/normal side ratio of the renal venous prostaglandin E2 correlated significantly with a renin ratio greater than 1.5 (r = 0.8211, p less than 0.05). Intravenous injection of aspirin DL-lysine (18 mg/kg) 30 minutes later markedly suppressed prostaglandin E2 and renin levels at all sites and clearly lowered arterial blood pressure (mean: from 120 +/- 6 to 110 +/- 5 mm Hg, p less than 0.01). The reduction in blood pressure correlated significantly with the suppression of plasma renin activity in the aorta (p less than 0.05) and in the renal vein of the stenotic kidney (p less than 0.01). Conversely, in patients with essential hypertension, aspirin had little effect on renin levels and increased mean blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
M Imanishi; M Kawamura; S Akabane; Y Matsushima; M Kuramochi; K Ito; M Ohta; K Kimura; M Takamiya; T Omae
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  14     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-19     Completed Date:  1989-12-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  461-8     Citation Subset:  IM    
Division of Hypertension and Nephrology, National Cardiovascular Center, Osaka, Japan.
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MeSH Terms
Aspirin / therapeutic use*
Blood Pressure / drug effects*
Dinoprostone / blood
Hemodynamics / drug effects
Hypertension, Renovascular / blood,  drug therapy*,  physiopathology
Osmolar Concentration
Renin / blood
Reg. No./Substance:
363-24-6/Dinoprostone; 50-78-2/Aspirin; EC

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