Document Detail

Aspirin intolerance. III. Subtypes, familial occurence, and cross-reactivity with tartarazine.
MedLine Citation:
PMID:  1151014     Owner:  NLM     Status:  MEDLINE    
Evidence has been presented supporting the hypothesis that at least 2 different types of mechanisms may be involved in aspirin intolerance, one resulting in bronchospasm and the other producing urticaria/angioedema. Bronchospasm is the predominant symptom of aspirin intolerance in patients who have asthma. In contrast, the predominant symptom of aspirin intolerance in patients who have rhinitis is urticaria/angioedema. In the bronchospastic type of aspirin intolerance, there is a significant correlation with an increased frequency of nasal polyposis, and with a similar ageonset of asthma and aspirin intolerance. These correlations were not present in the urticari/angioedema type. Additional evidence for familial occurrence of aspirin intolerance is presented, and its relationship with subtypes of aaspirin intolerance is discussed. In a double-blind, crossover study with normal control subjects matched by age and sex 15% (6/40) of aspirin-intolerant individuals had significant adverse reactions to tartrazine challenge and not to the placebo. None of the 40 normal control subjects had any adverse reactions.
G A Settipane; R K Pudupakkam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  56     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1975-11-07     Completed Date:  1975-11-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  215-21     Citation Subset:  AIM; IM    
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MeSH Terms
Angioedema / complications
Aspirin* / immunology*
Asthma / etiology
Azo Compounds / immunology*
Benzenesulfonates / immunology*
Bronchial Spasm / complications
Cross Reactions
Drug Hypersensitivity* / genetics,  immunology
Forced Expiratory Volume
Peak Expiratory Flow Rate
Respiratory Function Tests
Rhinitis, Allergic, Seasonal / etiology
Total Lung Capacity
Urticaria / complications
Vital Capacity
Reg. No./Substance:
0/Azo Compounds; 0/Benzenesulfonates; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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