Document Detail

Aspirin and heparin as adjuvants during IVF do not improve live birth rates in unexplained implantation failure.
MedLine Citation:
PMID:  23518029     Owner:  NLM     Status:  MEDLINE    
This study tested the hypothesis that using aspirin and/or heparin as adjuvants in IVF improves the treatment outcome. This retrospective cohort-control study recruited 234 consecutive subjects aged ≤ 44 years who had previously had one or more unsuccessful IVF cycle. All underwent IVF using conventional protocols. The study group received aspirin and/or heparin post embryo transfer until the day of pregnancy test or until 12 weeks of pregnancy. The control group did not receive adjuvant treatment. The outcome measures were live birth, clinical pregnancy and miscarriage rates. The outcomes were compared by chi-squared test and relative-risk analysis. Analysis was performed in 206 subjects. There was no statistically significant difference in the live birth rate (35.0%, 36/103 versus 47.6%, 49/103), clinical pregnancy rate (40.8%, 42/103 versus 53.4%, 55/103) and miscarriage rate (14.3%, 6/42 versus 10.9%, 6/55) between the study group and the control group. The data in this study show that low-dose aspirin and/or heparin as adjuvant therapies during IVF do not improve live birth rates in an unselected group of subfertile women who have previously had one or more unexplained implantation failure following IVF.
Muhammad A Akhtar; Hanan Eljabu; James Hopkisson; Nick Raine-Fenning; Siobhan Quenby; Kannamannadiar Jayaprakasan
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Publication Detail:
Type:  Journal Article     Date:  2013-02-18
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  26     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-05     Completed Date:  2014-01-02     Revised Date:  2014-02-14    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  586-94     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Aspirin / administration & dosage*
Birth Rate*
Embryo Implantation*
Fertilization in Vitro*
Heparin / administration & dosage*
Infant, Newborn
Infertility, Female
Infertility, Male
Retrospective Studies
Reg. No./Substance:
9005-49-6/Heparin; R16CO5Y76E/Aspirin
Comment In:
Reprod Biomed Online. 2014 Jan;28(1):133   [PMID:  24125945 ]
Reprod Biomed Online. 2013 Jun;26(6):538-41   [PMID:  23602681 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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