Document Detail

Aspirin desensitization for ASA triad patients--prospective study of the rhinologist`s perspective.
MedLine Citation:
PMID:  21468382     Owner:  NLM     Status:  MEDLINE    
METHODS OF STUDY: Patients with ASA triad were recruited from the outpatient otolaryngology clinic. They underwent a program of ASA desensitization (2005 - 2008) with prospective assessment of subjective and objective responses. Incremental doses of aspirin were given to reach a target of 625 mg twice daily during a period of 3 - 5 days. A maintenance dose was then given for the study period. The patients also received inhaled and topical nasal steroids, antihistamines and beta agonists for asthma control, but no systemic steroid treatment.
MAIN RESULTS: Of the original 27 enrolled subjects, 10 elected to discontinue treatment and five dropped out because of treatment complications. The objective evaluation of the polypoid sinonasal disease in the remaining 12 patients (4 males, 8 females, age range 22 - 63 years) revealed only mild improvement. In contrast, the patients` subjective feeling of nasal congestion, nasal discharge and overall discomfort improved significantly.
CONCLUSIONS: Aspirin desensitization has a favorable subjective effect on certain nasal symptoms among ASA triad patients, but the objective effect on polypoid mass is not significant.
B Forer; S Kivity; J Sade; R Landsberg
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rhinology     Volume:  49     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-06     Completed Date:  2011-05-26     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  95-9     Citation Subset:  IM    
Department of Otolaryngology, Head and Neck Surgery, Barzilai Medical Center, Ben Gurion University, Ashkelon, Israel.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / immunology*
Aspirin / immunology*
Asthma / drug therapy,  immunology*
Desensitization, Immunologic*
Drug Tolerance
Middle Aged
Nasal Polyps / drug therapy,  immunology*
Prospective Studies
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 50-78-2/Aspirin

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