Document Detail

Aspirin and congenital malformations.
MedLine Citation:
PMID:  59014     Owner:  NLM     Status:  MEDLINE    
In a cohort of 50 282 gravidas and their offspring in the U.S.A., malformation rates were similar in the children of 35 418 women not exposed to aspirin, 9736 with intermediate exposure, and 5128 women heavily exposed during the first four lunar months of pregnancy. After controlling a wide range of potential confounding factors using multi-variate analysis, the observed and expected numbers for a variety of malformation categories were similar in all three comparison groups. The data suggest that aspirin is not teratogenic.
D Slone; V Siskind; O P Heinonen; R R Monson; D W Kaufman; S Shapiro
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-23     Completed Date:  1976-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1373-5     Citation Subset:  AIM; IM; J    
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MeSH Terms
Abnormalities, Drug-Induced / etiology*
Abnormalities, Multiple / chemically induced
Aspirin / administration & dosage,  adverse effects*
Birth Weight / drug effects
Infant, Newborn
Infant, Newborn, Diseases / mortality
Maternal-Fetal Exchange
Smoking / complications
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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