Document Detail

Aspirin-associated intracerebral hemorrhage in a patient with CADASIL.
MedLine Citation:
PMID:  18207319     Owner:  NLM     Status:  MEDLINE    
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary disease characterized by ischemic stroke, cognitive impairment, migraine and neuropsychological deficit. Although intracerebral hemorrhage (ICH) has been described in patients with CADASIL, the cause of such ICH is still unknown. We present a 39-year-old man with CADASIL who had two years history of untreated hypertension. In this patient, acute ICH developed only two weeks after the initiation of aspirin. Brain images demonstrated a 3cmx3cm hyperacute ICH in the left temporal lobe at the site of previous old hemorrhage. The presence of cerebral microbleed and use of antithrombotics may be associated with development of ICH in patients with CADASIL.
Jung-Hwan Oh; Jung Seok Lee; Sa-Yoon Kang; Ji-Hoon Kang; Jay Chol Choi
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-01-22
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  110     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-04     Completed Date:  2008-07-15     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  384-6     Citation Subset:  IM    
Department of Neurology, Cheju National University School of Medicine, Jeju, Republic of Korea.
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MeSH Terms
Acute Disease
Aspirin / administration & dosage,  adverse effects*
CADASIL / complications*,  diagnosis
Cerebral Hemorrhage / chemically induced*,  diagnosis
Diffusion Magnetic Resonance Imaging
Follow-Up Studies
Platelet Aggregation Inhibitors / administration & dosage,  adverse effects*
Risk Factors
Stroke / prevention & control
Temporal Lobe / pathology
Tomography, X-Ray Computed
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin

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