Document Detail

Aspirin or anticoagulants in stenosis of the middle cerebral artery: A randomized trial.
MedLine Citation:
PMID:  16710082     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We report the results of an open, randomized, multicenter trial that compared the efficacy of aspirin to oral anticoagulants (OA) for the prevention of vascular events in patients with symptomatic stenosis of the middle cerebral artery (MCA). METHODS: Participants were randomly assigned to receive 300 mg/day of aspirin or a dose of OA (target INR 2-3). The MCA stenosis was demonstrated by conventional angiography or by at least two noninvasive examinations. Patients had either transient ischemic attack or cerebral infarct (CI) attributable to the MCA stenosis within 90 days before inclusion. The primary endpoint was: nonfatal CI, nonfatal acute myocardial infarct, vascular death and major hemorrhage. The patients were followed-up for a minimum of 1 year and a maximum of 3 years. RESULTS: The study included 28 patients (14 in each treatment group); the average age was 67 +/- 9.9 years. Men constituted 68% of the patients. After a mean follow-up of 23.1 +/- 10.9 months, there were no recurrences of CI in both groups. No endpoint was reported in the aspirin group, but 2 patients in the OA group (14.3%) exhibited vascular events: 1 acute myocardial infarct and 1 intracerebral hemorrhage). However, this difference was not statistically significant (p = 0.48). CONCLUSIONS: Our study suggests that aspirin is the treatment of choice for the prevention of vascular events in patients with symptomatic MCA stenosis.
J Martí-Fàbregas; D Cocho; J-L Martí-Vilalta; I Gich; R Belvís; Y Bravo; M Millán; M Castellanos; A Rodríguez-Campello; J Egido; D Geffner; A Gil-Núñez; J Marta; R Navarro; V Obach; E Palomeras
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-05-19
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  22     ISSN:  1015-9770     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-19     Completed Date:  2006-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  162-9     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
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MeSH Terms
Anticoagulants / pharmacology,  therapeutic use*
Aspirin / pharmacology,  therapeutic use*
Cerebral Arterial Diseases / complications,  drug therapy*,  pathology
Cerebrovascular Disorders / etiology,  prevention & control*
Constriction, Pathologic
Coumarins / pharmacology,  therapeutic use*
Middle Cerebral Artery / drug effects*,  pathology
Platelet Aggregation Inhibitors / pharmacology,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Anticoagulants; 0/Coumarins; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 91-64-5/coumarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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