| Aspirin, anticoagulants, and hemorrhagic conversion of ischemic infarction: hypothesis and implications. | |
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MedLine Citation:
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PMID: 3455245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anticoagulation may exacerbate possible tendencies for an ischemic infarction to become hemorrhagic. Little is known of any potential added risk of aspirin plus anticoagulation for such hemorrhagic transformation. A patient is reported who sustained a cerebral infarction from carotid artery disease and was treated with aspirin. Anticoagulation was begun and aspirin discontinued when the patient experienced a transient ischemic attack. Despite good control of anticoagulation, the patient sustained a hemorrhage at the site of infarction. The prolonged effects of aspirin combined with anticoagulants may have potentiated the conversion of an ischemic to a hemorrhagic infarction. Caution is advised when using anticoagulation immediately following aspirin therapy in patients with cerebral infarction. |
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Authors:
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M Fisher |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Bulletin of clinical neurosciences Volume: 51 ISSN: 0736-3583 ISO Abbreviation: Bull Clin Neurosci Publication Date: 1986 |
Date Detail:
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Created Date: 1988-10-20 Completed Date: 1988-10-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8411675 Medline TA: Bull Clin Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 68-72 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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adverse effects* Aspirin / adverse effects* Carotid Artery Diseases / radiography Cerebral Hemorrhage / chemically induced*, etiology, radiography Cerebral Infarction / complications* Heparin / adverse effects* Humans Ischemic Attack, Transient / etiology* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 50-78-2/Aspirin; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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