Document Detail

Aspirin, anticoagulants, and hemorrhagic conversion of ischemic infarction: hypothesis and implications.
MedLine Citation:
PMID:  3455245     Owner:  NLM     Status:  MEDLINE    
Anticoagulation may exacerbate possible tendencies for an ischemic infarction to become hemorrhagic. Little is known of any potential added risk of aspirin plus anticoagulation for such hemorrhagic transformation. A patient is reported who sustained a cerebral infarction from carotid artery disease and was treated with aspirin. Anticoagulation was begun and aspirin discontinued when the patient experienced a transient ischemic attack. Despite good control of anticoagulation, the patient sustained a hemorrhage at the site of infarction. The prolonged effects of aspirin combined with anticoagulants may have potentiated the conversion of an ischemic to a hemorrhagic infarction. Caution is advised when using anticoagulation immediately following aspirin therapy in patients with cerebral infarction.
M Fisher
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Bulletin of clinical neurosciences     Volume:  51     ISSN:  0736-3583     ISO Abbreviation:  Bull Clin Neurosci     Publication Date:  1986  
Date Detail:
Created Date:  1988-10-20     Completed Date:  1988-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8411675     Medline TA:  Bull Clin Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-72     Citation Subset:  IM    
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
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MeSH Terms
Anticoagulants / adverse effects*
Aspirin / adverse effects*
Carotid Artery Diseases / radiography
Cerebral Hemorrhage / chemically induced*,  etiology,  radiography
Cerebral Infarction / complications*
Heparin / adverse effects*
Ischemic Attack, Transient / etiology*
Middle Aged
Reg. No./Substance:
0/Anticoagulants; 50-78-2/Aspirin; 9005-49-6/Heparin

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