| Aspirin for Dual Prevention of Venous and Arterial Thrombosis. | |
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MedLine Citation:
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PMID: 23121404 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aspirin is conventionally regarded as an agent that prevents arterial thrombosis, an effect mediated through inhibition of platelet cyclooxygenase-1, resulting in decreased synthesis of thromboxane A(2) (platelet-activating eicosanoid). In high-risk patients, aspirin reduces by one quarter the frequency of arterial thrombosis.(1) In 1977, aspirin (at a dose of 600 mg twice daily) was shown to reduce the risk of venous thrombosis when it was given to patients after they had undergone hip arthoplasty.(2) Thirty-five years later, guidelines include aspirin as one option for preventing venous thromboembolism after orthopedic surgery.(3) However, many experts regard aspirin as inferior therapy for this . . . |
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Authors:
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Theodore E Warkentin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-4 |
Journal Detail:
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Title: The New England journal of medicine Volume: - ISSN: 1533-4406 ISO Abbreviation: N. Engl. J. Med. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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