Document Detail

Aspirin does not increase bleeding and allogeneic blood transfusion in coronary artery surgery.
MedLine Citation:
PMID:  21509719     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Traditionally, the administration of aspirin is stopped seven days before coronary artery bypass surgery to reduce the risk of postoperative bleeding. The aim of this study was to evaluate the effect of preoperative aspirin on bleeding in these patients.
METHODS: A prospective nonrandomized unblinded study was carried out at the King Abdullah University Hospital in Jordan/Irbid from June 2005 to December 2009 in 756 patients. Patients were divided into 2 groups: Group 1 (n = 400) consisted of patients on aspirin, 100 mg/day, until the day of surgery; Group 2 (n = 356) consisted of patients who stopped taking aspirin seven days before surgery. The groups were compared to evaluate the effect of preoperative aspirin on bleeding in patients undergoing elective coronary artery bypass surgery. Data were collected and compared and included total amount of postoperative chest tube drainage, number of transfused units of blood and blood products, and numbers of patients who required reexploration for bleeding. Results were considered significant when P < 0.05.
RESULTS: There was no significant increase in the amount of blood loss, units of transfused blood products, or the incidence of reexploration between the two groups ( P > 0.05).
CONCLUSION: Aspirin does not increase bleeding or increase the need for allogeneic blood transfusion in coronary artery surgery.
E Hijazi
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-04-20
Journal Detail:
Title:  The Thoracic and cardiovascular surgeon     Volume:  59     ISSN:  1439-1902     ISO Abbreviation:  Thorac Cardiovasc Surg     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-11     Completed Date:  2012-02-06     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  7903387     Medline TA:  Thorac Cardiovasc Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  421-4     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Division of Cardiac Surgery, Department of General Surgery, Princess Muna Al-Hussein Cardiac Center, King Abdullah University Hospital - Faculty of Medicine/Jordan University of Science and Technology, Irbid, Jordan.
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MeSH Terms
Aged, 80 and over
Aspirin / administration & dosage*,  adverse effects
Blood Transfusion*
Coronary Artery Bypass* / adverse effects
Drug Administration Schedule
Fibrinolytic Agents / administration & dosage*,  adverse effects
Hospitals, University
Middle Aged
Postoperative Hemorrhage / chemically induced,  prevention & control*
Prospective Studies
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Fibrinolytic Agents; 50-78-2/Aspirin
Erratum In:
Thorac Cardiovasc Surg. 2013 Apr;61(3):270

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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