Document Detail


Aspirin and clopidogrel alter core temperature and skin blood flow during heat stress.
MedLine Citation:
PMID:  23135368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The present double-blind, crossover study examined the functional consequences of 7 d of low-dose ASA (81 mg·d) versus CLO (75 mg·d) treatment in 14 healthy, middle-age (50-65 yr) men and women during passive heating in air (40 min at 30°C, 40% relative humidity) followed by exercise (60% V˙O2peak).
METHODS: Oral temperature (Tor) was measured in the antechamber (23.0°C ± 0.1°C) before entering a warm environmental chamber. After 40 min of rest, subjects cycled on a recumbent cycle ergometer for up to 120 min. Esophageal temperature (Tes) and laser Doppler flux were measured continuously, and the latter was normalized to maximal cutaneous vascular conductance (%CVCmax).
RESULTS: Before entry into the environmental chamber there were no differences in Tor among treatments; however, after 40 min of rest in the heat, Tes was significantly higher for ASA and CLO versus placebo (37.2°C ± 0.1°C, 37.3°C ± 0.1°C, vs 37.0°C ± 0.1°C, both P < 0.001), a difference that persisted throughout exercise (P < 0.001 vs placebo). The mean body temperature thresholds for the onset of cutaneous vasodilation were shifted to the right for both ASA and CLO during exercise (P < 0.05).
CONCLUSION: ASA and CLO resulted in elevated core temperatures during passive heat stress and shifted the onset of peripheral thermoeffector mechanisms toward higher body temperatures during exercise heat stress.
Authors:
Rebecca S Bruning; Jessica D Dahmus; W Larry Kenney; Lacy M Alexander
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  45     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-20     Completed Date:  2013-11-14     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  674-82     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aspirin / pharmacology*
Body Temperature Regulation / drug effects*
Cross-Over Studies
Double-Blind Method
Exercise Test / instrumentation,  methods
Female
Heat Stress Disorders / physiopathology,  prevention & control*
Humans
Laser-Doppler Flowmetry
Male
Middle Aged
Pennsylvania
Platelet Aggregation Inhibitors / pharmacology*
Regional Blood Flow / drug effects,  physiology
Skin / blood supply*
Thermography / methods
Ticlopidine / analogs & derivatives*,  pharmacology
Grant Support
ID/Acronym/Agency:
R01 AG007004/AG/NIA NIH HHS; R01 HL093238/HL/NHLBI NIH HHS; R21 HL-098645-02/HL/NHLBI NIH HHS; R21 HL098645/HL/NHLBI NIH HHS; UL1 TR000127/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; A74586SNO7/clopidogrel; OM90ZUW7M1/Ticlopidine; R16CO5Y76E/Aspirin
Comments/Corrections

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