Document Detail

Aspiration pneumonia: treatment with osmotically active agents.
MedLine Citation:
PMID:  6164109     Owner:  NLM     Status:  MEDLINE    
Utilizing the ex vivo perfused ventilated canine pulmonary lobe, we evaluated the effects of three osmotically active agents on pulmonary function after acid aspiration. Control lobes were stable during a 44-hour perfusion with minimal weight gain, stable pulmonary artery and end-inspiratory pressures, and no increase in intrapulmonary shunting. After acid aspiration during a 44-hour perfusion period, massive weight gain occurred (228 gm), pulmonary artery and end-inspiratory pressure increased, and marked intrapulmonary shunting (44%) developed. When mannitol (molecular weight 182) or dextran 40 (molecular weight 40,000) were added to the perfusate of the acid-instilled lobes, no significant modifications of the acid-induced response were seen during the 44-hour perfusion. The administration of albumin (molecular weight 69,000), however, markedly modified the acid-induced response. Weight gain (53 gm) was almost completely eliminated, pulmonary artery and end-inspiratory pressures were stable, and intrapulmonary shunting increased only minimally (10%). It is concluded that despite the permeability change in the capillary-alveolar membrane produced by acid aspiration, albumin is retained within the vascular space and is effective in reducing the injury response.
T J Toung; J L Cameron; T Kimura; S Permutt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery     Volume:  89     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  588-93     Citation Subset:  AIM; IM    
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MeSH Terms
Airway Resistance
Albumins / therapeutic use*
Blood Pressure
Dextrans / therapeutic use*
Lung / pathology
Mannitol / therapeutic use*
Organ Size
Pneumonia, Aspiration / drug therapy*
Pulmonary Artery / physiopathology
Time Factors
Reg. No./Substance:
0/Albumins; 69-65-8/Mannitol; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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