Document Detail


Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus.
MedLine Citation:
PMID:  19824618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited alpha-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the alpha-glucosidase from the bacterium Bacillus stearothermophilus.
Authors:
Nattha Ingavat; Jeffrey Dobereiner; Suthep Wiyakrutta; Chulabhorn Mahidol; Somsak Ruchirawat; Prasat Kittakoop
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of natural products     Volume:  72     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2009-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2049-52     Citation Subset:  IM    
Affiliation:
Chulabhorn Graduate Institute and the Center for Environmental Health, Toxicology and Management of Chemicals (ETM), Chemical Biology Program, Vibhavadi-Rangsit Road, Laksi, Bangkok 10210, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Aspergillus / chemistry*
Geobacillus stearothermophilus / drug effects,  enzymology*
Marine Biology
Molecular Structure
Saccharomyces cerevisiae / drug effects,  enzymology*
Stereoisomerism
Tyrosine / analogs & derivatives*,  chemistry,  isolation & purification,  pharmacology
Xanthones / isolation & purification
alpha-Glucosidases / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Xanthones; 0/aspergillusol A; 55520-40-6/Tyrosine; 56283-72-8/secalonic acid; EC 3.2.1.20/alpha-Glucosidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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