| Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus. | |
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MedLine Citation:
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PMID: 19824618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited alpha-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the alpha-glucosidase from the bacterium Bacillus stearothermophilus. |
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Authors:
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Nattha Ingavat; Jeffrey Dobereiner; Suthep Wiyakrutta; Chulabhorn Mahidol; Somsak Ruchirawat; Prasat Kittakoop |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of natural products Volume: 72 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-30 Completed Date: 2009-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 2049-52 Citation Subset: IM |
Affiliation:
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Chulabhorn Graduate Institute and the Center for Environmental Health, Toxicology and Management of Chemicals (ETM), Chemical Biology Program, Vibhavadi-Rangsit Road, Laksi, Bangkok 10210, Thailand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aspergillus
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chemistry* Geobacillus stearothermophilus / drug effects, enzymology* Marine Biology Molecular Structure Saccharomyces cerevisiae / drug effects, enzymology* Stereoisomerism Tyrosine / analogs & derivatives*, chemistry, isolation & purification, pharmacology Xanthones / isolation & purification alpha-Glucosidases / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Xanthones; 0/aspergillusol A; 55520-40-6/Tyrosine; 56283-72-8/secalonic acid; EC 3.2.1.20/alpha-Glucosidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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