| Aspergillus vertebral osteomyelitis in immunocompetent hosts: role of triazole antifungal therapy. | |
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MedLine Citation:
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PMID: 21148508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A review of published cases, in addition to a recently treated patient, is presented that describes the clinical features and outcomes of triazole therapy for vertebral aspergillosis in immunocompetent patients. METHODS: Using the Medline database, cases of vertebral aspergillosis in immunocompetent patients treated with triazole were reviewed. Clinical and radiological findings, therapeutic interventions, and outcomes were analyzed. RESULTS.: Twenty-one cases of vertebral aspergillosis treated with itraconazole or voriconazole were identified. Most cases were caused by Aspergillus fumigatus. The most common presenting symptom was back pain. The majority of cases were acquired by hematogenous infection, although one-quarter occurred after a spinal procedure. Most patients were treated successfully with a combination of antifungal therapy and surgery. Patients presenting with paraplegia had a poor outcome. The overall mortality rate was 20%. CONCLUSIONS: This report extends the information on invasive aspergillosis in immunocompetent patients and supports the conclusion that triazole therapy should be considered for this serious infection. |
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Authors:
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Alex Studemeister; David A Stevens |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 52 ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-03-28 Revised Date: 2011-05-06 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: e1-6 Citation Subset: IM |
Affiliation:
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Division of Infectious Diseases, San Jose Medical Group, San Jose, Carlifornia, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antifungal Agents / therapeutic use Aspergillosis / diagnosis*, microbiology Aspergillus fumigatus / isolation & purification* Female Humans Male Middle Aged Osteomyelitis / microbiology*, pathology* Spondylitis / microbiology*, pathology* Treatment Outcome Triazoles / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Triazoles |
| Comments/Corrections | |
Erratum In:
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Clin Infect Dis. 2011 Apr 1;52(7):966 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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