Document Detail

Aspergillus vertebral osteomyelitis in immunocompetent hosts: role of triazole antifungal therapy.
MedLine Citation:
PMID:  21148508     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A review of published cases, in addition to a recently treated patient, is presented that describes the clinical features and outcomes of triazole therapy for vertebral aspergillosis in immunocompetent patients.
METHODS: Using the Medline database, cases of vertebral aspergillosis in immunocompetent patients treated with triazole were reviewed. Clinical and radiological findings, therapeutic interventions, and outcomes were analyzed. RESULTS.: Twenty-one cases of vertebral aspergillosis treated with itraconazole or voriconazole were identified. Most cases were caused by Aspergillus fumigatus. The most common presenting symptom was back pain. The majority of cases were acquired by hematogenous infection, although one-quarter occurred after a spinal procedure. Most patients were treated successfully with a combination of antifungal therapy and surgery. Patients presenting with paraplegia had a poor outcome. The overall mortality rate was 20%.
CONCLUSIONS: This report extends the information on invasive aspergillosis in immunocompetent patients and supports the conclusion that triazole therapy should be considered for this serious infection.
Alex Studemeister; David A Stevens
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  52     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-03-28     Revised Date:  2011-05-06    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1-6     Citation Subset:  IM    
Division of Infectious Diseases, San Jose Medical Group, San Jose, Carlifornia, USA.
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MeSH Terms
Antifungal Agents / therapeutic use
Aspergillosis / diagnosis*,  microbiology
Aspergillus fumigatus / isolation & purification*
Middle Aged
Osteomyelitis / microbiology*,  pathology*
Spondylitis / microbiology*,  pathology*
Treatment Outcome
Triazoles / therapeutic use
Reg. No./Substance:
0/Antifungal Agents; 0/Triazoles
Erratum In:
Clin Infect Dis. 2011 Apr 1;52(7):966

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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