| The Aspergillus nidulans pkcA gene is involved in polarized growth, morphogenesis and maintenance of cell wall integrity. | |
| | |
MedLine Citation:
|
PMID: 17406869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The protein kinase C (PKC) family participates in maintaining integrity and growth of fungal cell walls. However, the precise molecular role of these proteins in the filamentous fungi remains unknown. In this work, pkcA, the gene encoding the PKC homolog in the filamentous fungus Aspergillus nidulans, was cloned and its function analyzed using a conditional alcA-PKC mutant strain. Repression of pkcA expression resulted in increased conidial swelling, decreased rates of hyphal growth, changes in the ultrastructure of the cell wall and increased sensitivity to antifungal agents. These results suggest that the protein encoded by pkcA is involved in key aspects of cell morphogenesis and cell wall integrity. |
| | |
Authors:
|
Revital Ronen; Haim Sharon; Emma Levdansky; Jacob Romano; Yona Shadkchan; Nir Osherov |
Related Documents
:
|
20365209 - Curvature and shape determination of growing bacteria. 17496119 - Udp-glucose 4-epimerase isoforms uge2 and uge4 cooperate in providing udp-galactose for... 17483219 - An antibiotic-inducible cell wall-associated protein that protects bacillus subtilis fr... 11762169 - Analysis of the distribution of copper amine oxidase in cell walls of legume seedlings. 1368079 - Combined chemical and mechanical processes for the disruption of bacteria. 21786169 - Valproic acid induced differentiation and potentiated efficacy of taxol and nanotaxol f... 17106869 - The water extract of omija protects h9c2 cardiomyoblast cells from hydrogen peroxide th... 18597339 - Kinetic analysis of the effects of plasmid multimerization on segregational instability... 9162049 - Interleukin-1beta secreted from monocytic cells induces the expression of matrilysin in... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-04 |
Journal Detail:
|
Title: Current genetics Volume: 51 ISSN: 0172-8083 ISO Abbreviation: Curr. Genet. Publication Date: 2007 May |
Date Detail:
|
Created Date: 2007-04-16 Completed Date: 2007-07-26 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 8004904 Medline TA: Curr Genet Country: United States |
Other Details:
|
Languages: eng Pagination: 321-9 Citation Subset: IM |
Affiliation:
|
Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aspergillus nidulans
/
enzymology*,
genetics,
growth & development,
physiology Cell Wall / metabolism Fungal Proteins / genetics, physiology* Glucose / metabolism Hyphae / metabolism Mutation Protein Kinase C-alpha / genetics, physiology* Spores, Fungal / growth & development |
| Chemical | |
Reg. No./Substance:
|
0/Fungal Proteins; 50-99-7/Glucose; EC 2.7.11.13/Protein Kinase C-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity f...
Next Document: Seronegative Lyme arthritis.