Document Detail

Aspergillus meningitis : a rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases.
MedLine Citation:
PMID:  23178421     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To describe the pathogenesis, clinical presentation, cerebrospinal fluid findings and outcome of Aspergillus meningitis, meningoencephalitis and arachnoiditis. METHODS: A case of Aspergillus meningitis is described. A comprehensive review of the English-language literature was conducted to identify all reported cases of Aspergillus meningitis described between January 1973 and December 2011. RESULTS: Ninety-three cases (including the one described herein) of Aspergillus meningitis were identified. Fifty-two (55.9 %) were in individuals without any predisposing factor or known causes of immunosuppression. Acute and chronic meningitis was diagnosed in 65.6 % of patients and meningoencephalitis in 24.7 % of them with the remaining presenting with spinal arachnoiditis and ventriculitis. Cerebrospinal fluid cultures for Aspergillus spp. were positive in about 31 % of cases and the galactomannan antigen test in 87 %. Diagnosis during life was achieved in 52 patients (55.9 %) with a case fatality rate of 50 %. The overall case fatality rate was 72.1 %. CONCLUSIONS: Aspergillus meningitis may occur in both immunocompetent and immunocompromised patients and run an acute or chronic course. The findings of this systematic review extend the information on this life-threatening infection and could assist physicians in achieving an improved outcome.
Spinello Antinori; Mario Corbellino; Luca Meroni; Federico Resta; Salvatore Sollima; Massimo Tonolini; Anna Maria Tortorano; Laura Milazzo; Lorenzo Bello; Elisa Furfaro; Massimo Galli; Claudio Viscoli
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-21
Journal Detail:
Title:  The Journal of infection     Volume:  -     ISSN:  1532-2742     ISO Abbreviation:  J. Infect.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7908424     Medline TA:  J Infect     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Department Of Biomedical And Clinical Sciences Luigi Sacco, Università Di Milano, Milano, Italy. Electronic address:
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