| Aspergillus meningitis : a rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases. | |
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MedLine Citation:
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PMID: 23178421 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: To describe the pathogenesis, clinical presentation, cerebrospinal fluid findings and outcome of Aspergillus meningitis, meningoencephalitis and arachnoiditis. METHODS: A case of Aspergillus meningitis is described. A comprehensive review of the English-language literature was conducted to identify all reported cases of Aspergillus meningitis described between January 1973 and December 2011. RESULTS: Ninety-three cases (including the one described herein) of Aspergillus meningitis were identified. Fifty-two (55.9 %) were in individuals without any predisposing factor or known causes of immunosuppression. Acute and chronic meningitis was diagnosed in 65.6 % of patients and meningoencephalitis in 24.7 % of them with the remaining presenting with spinal arachnoiditis and ventriculitis. Cerebrospinal fluid cultures for Aspergillus spp. were positive in about 31 % of cases and the galactomannan antigen test in 87 %. Diagnosis during life was achieved in 52 patients (55.9 %) with a case fatality rate of 50 %. The overall case fatality rate was 72.1 %. CONCLUSIONS: Aspergillus meningitis may occur in both immunocompetent and immunocompromised patients and run an acute or chronic course. The findings of this systematic review extend the information on this life-threatening infection and could assist physicians in achieving an improved outcome. |
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Authors:
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Spinello Antinori; Mario Corbellino; Luca Meroni; Federico Resta; Salvatore Sollima; Massimo Tonolini; Anna Maria Tortorano; Laura Milazzo; Lorenzo Bello; Elisa Furfaro; Massimo Galli; Claudio Viscoli |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-21 |
Journal Detail:
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Title: The Journal of infection Volume: - ISSN: 1532-2742 ISO Abbreviation: J. Infect. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7908424 Medline TA: J Infect Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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Department Of Biomedical And Clinical Sciences Luigi Sacco, Università Di Milano, Milano, Italy. Electronic address: spinello.antinori@unimi.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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