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Aspergillus fumigatus colonization in cystic fibrosis: implications for lung function?
MedLine Citation:
PMID:  21087348     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Clin Microbiol Infect 2011; 17: 1381-1386 ABSTRACT: Aspergillus fumigatus is commonly found in the respiratory secretions of patients with cystic fibrosis (CF). Although allergic bronchopulmonary aspergillosis (ABPA) is associated with deterioration of lung function, the effects of A. fumigatus colonization on lung function in the absence of ABPA are not clear. This study was performed in 259 adults and children with CF, without ABPA. A. fumigatus colonization was defined as positivity of >50% of respiratory cultures in a given year. A cross-sectional analysis was performed to study clinical characteristics associated with A. fumigatus colonization. A retrospective cohort analysis was performed to study the effect of A. fumigatus colonization on lung function observed between 2002 and 2007. Longitudinal data were analysed with a linear mixed model. Sixty-one of 259 patients were at least intermittently colonized with A. fumigatus. An association was found between A. fumigatus colonization and increased age and use of inhaled antibiotics. In the longitudinal analysis, 163 patients were grouped according to duration of colonization. After adjustment for confounders, there was no significant difference in lung function between patients colonized for 0 or 1 year and patients with 2-3 or more than 3 years of colonization (p 0.40 and p 0.64) throughout the study. There was no significant difference in lung function decline between groups. Although colonization with A. fumigatus is more commonly found in patients with more severe lung disease and increased treatment burden, it is not independently associated with lower lung function or more severe lung function decline over a 5-year period.
Authors:
A M M de Vrankrijker; C K van der Ent; F T van Berkhout; R K Stellato; R J L Willems; M J M Bonten; T F W Wolfs
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Publication Detail:
Type:  Journal Article     Date:  2010-12-16
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  17     ISSN:  1469-0691     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  1381-6     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.
Affiliation:
Department of Paediatric Respiratory Medicine  Department of Pulmonology  Biostatistics, Julius Centre for Health Sciences and Primary Care  Department of Medical Microbiology  Department of Paediatric Infectious Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands.
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