| Aspergillus fumigatus challenge increases cytokine levels in nasal lavage fluid. | |
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MedLine Citation:
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PMID: 16966303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies have shown an association between exposure in moisture-damaged buildings and adverse health effects. There are several indicator microbes of moisture damage, but Aspergillus fumigatus is one of the best-documented molds provoking health problems in different occupational conditions. We assessed whether inhalation of a commercial A. fumigatus solution would affect cytokine levels (tumor necrosis factor [TNF]-alpha, interleukin [IL]-1beta, IL-4, IL-6, interferon [IFN]-gamma) in nasal lavage fluid (NAL) compared with that evoked by placebo challenge. Twenty-seven subjects were studied: 13 had occupational exposure in a moisture-damaged building, 4 were atopic, and 10 were considered as controls. In all the subjects, the IL-1beta levels were increased significantly both at 6 (p = 0.013) and 24 h (p = .005) after the A. fumigatus challenge compared to placebo. In subjects with previous occupational exposure in a moisture-damaged building, IL-4 concentrations were increased significantly both at 6 (p =.046) and 24 h (p =.008) after the A. fumigatus challenge compared with placebo. Furthermore, in the control group, TNF-alpha levels were significantly increased at 6 h after the A. fumigatus challenge compared to placebo (p = .028). Thus, these data show a link between markers of inflammation in NAL and experimental A. fumigatus challenge. |
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Authors:
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H Stark; M Roponen; M Purokivi; J Randell; H Tukiainen; M-R Hirvonen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Inhalation toxicology Volume: 18 ISSN: 1091-7691 ISO Abbreviation: Inhal Toxicol Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-09-12 Completed Date: 2006-09-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8910739 Medline TA: Inhal Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 1033-9 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland. harri.stark@kuh.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Air Microbiology Aspergillus fumigatus / pathogenicity* Female Humans Humidity Inflammation Mediators / analysis*, metabolism Inhalation Exposure* Interferon-gamma / analysis*, biosynthesis Interleukin-1 / analysis*, biosynthesis Interleukin-4 / analysis*, biosynthesis Middle Aged Nasal Lavage Fluid / chemistry*, cytology, microbiology Occupational Exposure Time Factors Tumor Necrosis Factor-alpha / analysis*, biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/IL4 protein, human; 0/Inflammation Mediators; 0/Interleukin-1; 0/Tumor Necrosis Factor-alpha; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma |
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