Document Detail


Aspergilloxide, a novel sesterterpene epoxide from a marine-derived fungus of the genus Aspergillus.
MedLine Citation:
PMID:  11975634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
[structure: see text]. A new sesterterpene epoxide-diol, aspergilloxide (1), was isolated from the extract of a cultured marine-derived fungus (strain CNM-713) identified as an undescribed member of the genus Aspergillus. The structure of 1 was determined by interpretation of NMR data and by chemical methods. The absolute stereochemistry of aspergilloxide was assigned by application of the modified Mosher method. The carbon skeleton of 1 represents a new addition to the architectural diversity of the sesterterpenoid (C25) class of secondary metabolites.
Authors:
Mercedes Cueto; Paul R Jensen; William Fenical
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Organic letters     Volume:  4     ISSN:  1523-7060     ISO Abbreviation:  Org. Lett.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-26     Completed Date:  2002-06-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1583-5     Citation Subset:  IM    
Affiliation:
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetylation
Antibiotics, Antineoplastic / chemistry*,  pharmacology
Aspergillus / chemistry*
Drug Screening Assays, Antitumor
Epoxy Compounds / chemistry*,  pharmacology
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Conformation
Terpenes / chemistry*,  pharmacology
Tumor Cells, Cultured
Grant Support
ID/Acronym/Agency:
CA44848/CA/NCI NIH HHS; CA67775/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Epoxy Compounds; 0/Terpenes; 0/aspergilloxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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