| Asperfuranone from Aspergillus nidulans inhibits proliferation of human non-small cell lung cancer A549 cells via blocking cell cycle progression and inducing apoptosis. | |
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MedLine Citation:
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PMID: 20148857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asperfuranone, a novel compound of genomic mining in Aspergillus nidulans, was investigated for its anti-proliferative activity in human non-small cell lung cancer A549 cells. To identity the anti-cancer mechanism of asperfuranone, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21 Waf1/Cip1, Fas/APO-1 receptor and Fas ligand. Enzyme-linked immunosorbent assay showed that the G0/G1 phase arrest might be due to p53-dependent induction of p21 Waf1/Cip1. An enhancement in Fas/APO-1 and its two form ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), might be responsible for the apoptotic effect induced by asperfuranone. Our study reports here for the first time that the induction of p53 and the activity of Fas/Fas ligand apoptotic system may participate in the anti-proliferative activity of asperfuranone in A549 cells. |
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Authors:
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Clay C C Wang; Yi-Ming Chiang; Mike B Praseuth; Po-Lin Kuo; Hsin-Lin Liang; Ya-Ling Hsu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-02-09 |
Journal Detail:
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Title: Basic & clinical pharmacology & toxicology Volume: 107 ISSN: 1742-7843 ISO Abbreviation: Basic Clin. Pharmacol. Toxicol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-10-12 Revised Date: 2012-11-16 |
Medline Journal Info:
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Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: Denmark |
Other Details:
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Languages: eng Pagination: 583-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Pharmaceutical Science, University of Southern California, School of Pharmacy, Los Angeles, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology* Apoptosis / drug effects Aspergillus nidulans / chemistry* Benzofurans / pharmacology* Carcinoma, Non-Small-Cell Lung / drug therapy*, metabolism, pathology Cell Cycle / drug effects, physiology Cell Line, Tumor Cell Proliferation / drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Female Humans Lung Neoplasms / drug therapy*, metabolism, pathology Tumor Markers, Biological / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P01 GM084077/GM/NIGMS NIH HHS; P01 GM084077-05/GM/NIGMS NIH HHS; P01GM084077/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Benzofurans; 0/Tumor Markers, Biological; 0/asperfuranone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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