Document Detail


Asperfuranone from Aspergillus nidulans inhibits proliferation of human non-small cell lung cancer A549 cells via blocking cell cycle progression and inducing apoptosis.
MedLine Citation:
PMID:  20148857     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asperfuranone, a novel compound of genomic mining in Aspergillus nidulans, was investigated for its anti-proliferative activity in human non-small cell lung cancer A549 cells. To identity the anti-cancer mechanism of asperfuranone, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21 Waf1/Cip1, Fas/APO-1 receptor and Fas ligand. Enzyme-linked immunosorbent assay showed that the G0/G1 phase arrest might be due to p53-dependent induction of p21 Waf1/Cip1. An enhancement in Fas/APO-1 and its two form ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), might be responsible for the apoptotic effect induced by asperfuranone. Our study reports here for the first time that the induction of p53 and the activity of Fas/Fas ligand apoptotic system may participate in the anti-proliferative activity of asperfuranone in A549 cells.
Authors:
Clay C C Wang; Yi-Ming Chiang; Mike B Praseuth; Po-Lin Kuo; Hsin-Lin Liang; Ya-Ling Hsu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-02-09
Journal Detail:
Title:  Basic & clinical pharmacology & toxicology     Volume:  107     ISSN:  1742-7843     ISO Abbreviation:  Basic Clin. Pharmacol. Toxicol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-01     Completed Date:  2010-10-12     Revised Date:  2012-11-16    
Medline Journal Info:
Nlm Unique ID:  101208422     Medline TA:  Basic Clin Pharmacol Toxicol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  583-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Pharmaceutical Science, University of Southern California, School of Pharmacy, Los Angeles, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects
Aspergillus nidulans / chemistry*
Benzofurans / pharmacology*
Carcinoma, Non-Small-Cell Lung / drug therapy*,  metabolism,  pathology
Cell Cycle / drug effects,  physiology
Cell Line, Tumor
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Female
Humans
Lung Neoplasms / drug therapy*,  metabolism,  pathology
Tumor Markers, Biological / metabolism
Grant Support
ID/Acronym/Agency:
P01 GM084077/GM/NIGMS NIH HHS; P01 GM084077-05/GM/NIGMS NIH HHS; P01GM084077/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Benzofurans; 0/Tumor Markers, Biological; 0/asperfuranone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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