Document Detail

Aspects of the renal phenotype of adult alpha8 integrin-deficient mice.
MedLine Citation:
PMID:  12386295     Owner:  NLM     Status:  MEDLINE    
Integrins mediate cell-matrix interactions which are important for organ development. In the kidney, alpha8 integrin is expressed during early nephrogenesis. In alpha8 gene-mutated mice, lack of alpha8 leads to unilateral or bilateral renal agenesis in part of the animals. We investigated surviving animals with one or two kidneys. These mice had significantly reduced renal mass and displayed higher blood pressure compared with the wild-type. Furthermore, most of them revealed urine concentration defects. Many alpha8-deficient mice also exhibited segmental malformations of the kidney with collapse or atrophy of tubuli and interstitial cell infiltrates. These data provide further evidence that alpha8 has important functions in renal development.
Andrea Hartner; Christian Haas; Kerstin Amann; R Bernd Sterzel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  17 Suppl 9     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2002  
Date Detail:
Created Date:  2002-10-18     Completed Date:  2003-03-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  71-2     Citation Subset:  IM    
Med Klinik IV, Universität Erlangen-Nürnberg, Germany.
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MeSH Terms
Blood Pressure
Congenital Abnormalities / pathology,  physiopathology
Integrin alpha Chains / deficiency*,  genetics
Kidney / abnormalities,  pathology,  physiopathology*
Mice, Knockout / genetics
Reg. No./Substance:
0/Integrin alpha Chains; 0/integrin alpha8

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