Document Detail

Aspects on receptor regulation and isoreceptor identification.
MedLine Citation:
PMID:  6167826     Owner:  NLM     Status:  MEDLINE    
The present paper introduces a classification of receptor regulation. This classification takes into consideration especially the type of regulation (homoregulation vs. heteroregulation) and the biochemical mechanisms subserving the regulation process. Furthermore, criteria for isoreceptor identification are introduced on a quantitative basis, that is by means of comparisons of ED50 values obtained, using a certain agonist, for the different responses triggered by the binding of the ligand with the respective class of receptors. Finally, a possible case of isoreceptor interconversion is extensively discussed and a model for such an interconversion is suggested.
L F Agnati; K Fuxe; I Zini; P Lenzi; T Hökfelt
Related Documents :
6302116 - Ligand/receptor internalization: a spectroscopic analysis and a comparison of ligand bi...
6714426 - Ligand-specific state transitions of the membrane-bound acetylcholine receptor.
12909256 - Modelling of signalling via g-protein coupled receptors: pathway-dependent agonist pote...
9473266 - Pharmacological constraints associated with positron emission tomographic scanning of s...
23872416 - "are melanocortin receptors constitutively active in vivo?"
11683896 - Taurine selectively modulates the secretory activity of vasopressin neurons in consciou...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medical biology     Volume:  58     ISSN:  0302-2137     ISO Abbreviation:  Med. Biol.     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1981-10-14     Completed Date:  1981-10-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0417300     Medline TA:  Med Biol     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  182-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Binding Sites*
Lysergic Acid Diethylamide / metabolism
Neurotransmitter Agents / physiology
Receptors, Adrenergic, beta / metabolism
Receptors, Cell Surface / metabolism
Serotonin / physiology
Substance P / physiology
Grant Support
Reg. No./Substance:
0/Neurotransmitter Agents; 0/Receptors, Adrenergic, beta; 0/Receptors, Cell Surface; 33507-63-0/Substance P; 50-37-3/Lysergic Acid Diethylamide; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bepridil blockade of Ca2+-dependent action potentials in vascular smooth muscle of dog coronary arte...
Next Document:  Topography of chemically identified neurons in the central nervous system: progress in 1977-1979.