| Aspects of prostaglandin action in asthma. | |
| | |
MedLine Citation:
|
PMID: 998438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Eight patients with type I allergic bronchial asthma were given specific allergens by inhalation until symptoms and signs of asthma attacks were provoked. In some of these patients the provocation was repeated with premediciation of heparin, theofyllamin, small doses of cortisone (beclomethasone inhalations) or pretreatment within indomethacin. Before and after the provocation as in the three patients with exercise-induced asthma, peripheral venous blood sampled and analyzed for 15-keto-13,14-dihydro-PGF2alpha using combined gas--liquid chromatography-mass spectrometry. The allergen or exercise-provoked asthmatic attacks were associated with an up to eightfold increase in 15-keto-13,14-dihydro-PGF2alpha, the main metabolite of PGF2alpha in plasma. The increase in PGF2alpha metabolite which could be demonstrated within a few minutes after starting the provocation or finishing the exercise test seemed to be correlated to the severity of the attack in the allergic asthma but not clearly in exercise asthma. Pretreatment with different drugs did not give significant change in allergen sensitivity or plasma metabolite of PGF2alpha, except after pretreatment with indomethacin where one patient showed a fairly unchanged allergen sensitivity but a marked decrease in the plasma level of the PGF2alpha metabolite. The role of prostaglandins, their precursers and intermediates in prostaglandin synthesis, in the pathogenesis of asthma is indeed complex. |
| | |
Authors:
|
N Svanborg; P Hedqvist; K Gréen |
Related Documents
:
|
16524708 - Autonomic nervous system control of the cardiovascular and respiratory systems in asthma. 821168 - Inhibition of exercise-induced asthma by different pharmacological pathways. 6119168 - Oxatomide and exercise-induced asthma in children: the value of serial exercise tests. 12238628 - 5-hydroxyindolacetic acid and homovanillic acid are not involved in the cerebrospinal f... 12971708 - The effectiveness of intensive group exercise on patients with ankylosing spondylitis. 8391948 - Effects of enalaprilat on sympathetic activity and metabolism of exercising muscles in ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Advances in prostaglandin and thromboxane research Volume: 1 ISSN: 0361-5952 ISO Abbreviation: Adv Prostaglandin Thromboxane Res Publication Date: 1976 |
Date Detail:
|
Created Date: 1977-01-25 Completed Date: 1977-01-25 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7610366 Medline TA: Adv Prostaglandin Thromboxane Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 439-47 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Allergens Asthma / blood*, physiopathology Cortisone / pharmacology Female Heparin / pharmacology Humans Indomethacin / pharmacology Male Physical Exertion Prostaglandins F / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Allergens; 0/Prostaglandins F; 53-06-5/Cortisone; 53-86-1/Indomethacin; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antiarrhythmic effects of arachidonic, linoleic, linolenic, and oleic acid, and the influence of ind...
Next Document: Involvement of endoperoxides and thromboxanes in anaphylactic reactions.