| Aspects of placental growth hormone physiology. | |
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MedLine Citation:
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PMID: 16632396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Placental growth hormone (PGH) has been known for 20 years. Nevertheless, its physiology is far from understood. In this review, basal aspects of PGH physiology are summarised and put in relation to the highly homologous pituitary growth hormone (GH). During normal pregnancy, PGH progressively replaces GH and reach maximum serum concentrations in the third trimester. A close relationship to insulin-like growth factor (IGF)-I and -II levels is observed. Furthermore, PGH levels are positively associated to fetal growth. The potential importance of growth hormone receptors and binding protein for PGH effects is discussed. Finally, the review outlines current knowledge of PGH in pathological pregnancies. |
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Authors:
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Jens Fuglsang; Per Ovesen |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-04-24 |
Journal Detail:
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Title: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society Volume: 16 ISSN: 1096-6374 ISO Abbreviation: Growth Horm. IGF Res. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-05-29 Completed Date: 2006-11-03 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 9814320 Medline TA: Growth Horm IGF Res Country: Scotland |
Other Details:
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Languages: eng Pagination: 67-85 Citation Subset: IM |
Affiliation:
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Gynaecological/Obstetrical Research Laboratory Y, Aarhus University Hospital, Skejby Sygehus, DK-8200 Aarhus N, Denmark. Fuglsang@ki.au.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Growth Hormone / blood*, genetics Humans Placental Hormones / blood*, genetics Pregnancy / blood* Pregnancy Complications / blood, pathology Pregnancy Trimester, Third / blood* Sequence Homology, Amino Acid |
| Chemical | |
Reg. No./Substance:
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0/GH2 protein, human; 0/Placental Hormones; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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