Document Detail

Aspects of placental growth hormone physiology.
MedLine Citation:
PMID:  16632396     Owner:  NLM     Status:  MEDLINE    
Placental growth hormone (PGH) has been known for 20 years. Nevertheless, its physiology is far from understood. In this review, basal aspects of PGH physiology are summarised and put in relation to the highly homologous pituitary growth hormone (GH). During normal pregnancy, PGH progressively replaces GH and reach maximum serum concentrations in the third trimester. A close relationship to insulin-like growth factor (IGF)-I and -II levels is observed. Furthermore, PGH levels are positively associated to fetal growth. The potential importance of growth hormone receptors and binding protein for PGH effects is discussed. Finally, the review outlines current knowledge of PGH in pathological pregnancies.
Jens Fuglsang; Per Ovesen
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-04-24
Journal Detail:
Title:  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society     Volume:  16     ISSN:  1096-6374     ISO Abbreviation:  Growth Horm. IGF Res.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-29     Completed Date:  2006-11-03     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  9814320     Medline TA:  Growth Horm IGF Res     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  67-85     Citation Subset:  IM    
Gynaecological/Obstetrical Research Laboratory Y, Aarhus University Hospital, Skejby Sygehus, DK-8200 Aarhus N, Denmark.
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MeSH Terms
Growth Hormone / blood*,  genetics
Placental Hormones / blood*,  genetics
Pregnancy / blood*
Pregnancy Complications / blood,  pathology
Pregnancy Trimester, Third / blood*
Sequence Homology, Amino Acid
Reg. No./Substance:
0/GH2 protein, human; 0/Placental Hormones; 9002-72-6/Growth Hormone

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