Document Detail


Aspects of human fetoplacental vasculogenesis and angiogenesis. II. Changes during normal pregnancy.
MedLine Citation:
PMID:  14972444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this second review, we describe the main morphological events which accompany the development of the fetoplacental vascular system throughout normal human pregnancy and summarize findings on the expression of angiogenic growth factors and their receptors. Fetoplacental vasculogenesis starts at day 21 after conception by formation of haemangioblastic cords. In the following phase of branching angiogenesis (day 32 to week 25 post conception), haemangioblastic cords develop into a richly branched villous capillary bed with low fetoplacental blood flow impedance. This period is characterized by high placental levels of VEGF but moderate PlGF expression. In week 15, large centrally located villi show regression of peripheral capillary nets. In parallel, some remaining central capillaries acquire a tunica media and transform into arteries and veins. Beginning at about week 25 in the newly formed peripheral villi, angiogenesis switches from branching to non-branching and this period is accompanied by a steep drop in VEGF and a slower decline in PlGF expression. As a consequence of this switch, long poorly branched capillary loops are formed in the periphery of the fetoplacental vascular trees. These increase fetoplacental impedance but blood flow still increases due to rising fetal blood pressure. The possible interactions between (a). the biphasic development of intraplacental oxygen tensions, (b). changes in VEGF and PlGF levels and (c). developing vascular geometry are discussed. Special attention is given to the obvious discrepancy between sudden elevation of intervillous oxygen tensions which is not coincident with the appearance of angiogenic growth factor peaks and the switch from branching to non-branching angiogenesis. Finally, we deal with methods of quantifying aspects of angiogenesis in the villous vascular system and summarize the main findings during uncomplicated human pregnancy.
Authors:
P Kaufmann; T M Mayhew; D S Charnock-Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Placenta     Volume:  25     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    2004 Feb-Mar
Date Detail:
Created Date:  2004-02-19     Completed Date:  2004-09-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  114-26     Citation Subset:  IM    
Affiliation:
Department of Anatomy II, University Hospital, RWTH-Aachen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Capillaries / growth & development,  metabolism
Chorionic Villi / blood supply*,  growth & development*,  metabolism
Female
Gestational Age
Humans
Membrane Proteins
Neovascularization, Physiologic*
Pregnancy / physiology*
Proteins / metabolism
Vascular Endothelial Growth Factor A / metabolism
Chemical
Reg. No./Substance:
0/Membrane Proteins; 0/PIGF protein, human; 0/Proteins; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A

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