Document Detail

Aspects of the effect of bile salts on Candida albicans.
MedLine Citation:
PMID:  3323449     Owner:  NLM     Status:  MEDLINE    
Cholic acid, chenodeoxycholic acid, deoxycholic acid, glycocholic acid, glycodeoxycholic acid, hyodeoxycholic acid and lithocholic acid as their sodium salts, were fungistatic to the growth of Candida albicans. Of the compounds tested, cholic acid, deoxycholic acid and chenodeoxycholic acid were the most active. In combination with other antifungal agents only cholic acid exhibited synergism with amphotericin B, whilst the imidazole antifungal agents inhibited the action of the bile salts. The bile salt minimal inhibitory concentrations were close to the critical micelle concentrations. Even though the compounds are surface active they did not cause loss of intracellular K+ and were without effect on oxygen consumption. The bile salts, particularly cholic acid, produced morphological changes that gave rise to swollen cells.
S E Marshall; B A Marples; W G Salt; R J Stretton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology     Volume:  25     ISSN:  0268-1218     ISO Abbreviation:  J. Med. Vet. Mycol.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-03-07     Completed Date:  1988-03-07     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  8605493     Medline TA:  J Med Vet Mycol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  307-18     Citation Subset:  IM    
Department of Chemistry, Loughborough University of Technology, Leicestershire, U.K.
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MeSH Terms
Amphotericin B / pharmacology
Antifungal Agents / pharmacology
Bile Acids and Salts / antagonists & inhibitors,  pharmacology*
Candida albicans / cytology,  drug effects*,  growth & development
Chenodeoxycholic Acid / pharmacology
Cholic Acid
Cholic Acids / pharmacology*
Deoxycholic Acid / pharmacology
Drug Synergism
Oxygen Consumption / drug effects
Potassium / metabolism
Reg. No./Substance:
0/Antifungal Agents; 0/Bile Acids and Salts; 0/Cholic Acids; 1397-89-3/Amphotericin B; 474-25-9/Chenodeoxycholic Acid; 7440-09-7/Potassium; 81-25-4/Cholic Acid; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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