| Aspartame: review of safety. | |
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MedLine Citation:
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PMID: 12180494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over 20 years have elapsed since aspartame was approved by regulatory agencies as a sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was established through extensive toxicology studies in laboratory animals, using much greater doses than people could possibly consume. Its safety was further confirmed through studies in several human subpopulations, including healthy infants, children, adolescents, and adults; obese individuals; diabetics; lactating women; and individuals heterozygous (PKUH) for the genetic disease phenylketonuria (PKU) who have a decreased ability to metabolize the essential amino acid, phenylalanine. Several scientific issues continued to be raised after approval, largely as a concern for theoretical toxicity from its metabolic components--the amino acids, aspartate and phenylalanine, and methanol--even though dietary exposure to these components is much greater than from aspartame. Nonetheless, additional research, including evaluations of possible associations between aspartame and headaches, seizures, behavior, cognition, and mood as well as allergic-type reactions and use by potentially sensitive subpopulations, has continued after approval. These findings are reviewed here. The safety testing of aspartame has gone well beyond that required to evaluate the safety of a food additive. When all the research on aspartame, including evaluations in both the premarketing and postmarketing periods, is examined as a whole, it is clear that aspartame is safe, and there are no unresolved questions regarding its safety under conditions of intended use. |
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Authors:
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Harriett H Butchko; W Wayne Stargel; C Phil Comer; Dale A Mayhew; Christian Benninger; George L Blackburn; Leo M J de Sonneville; Raif S Geha; Zsolt Hertelendy; Adalbert Koestner; Arthur S Leon; George U Liepa; Kenneth E McMartin; Charles L Mendenhall; Ian C Munro; Edward J Novotny; Andrew G Renwick; Susan S Schiffman; Donald L Schomer; Bennett A Shaywitz; Paul A Spiers; Thomas R Tephly; John A Thomas; Friedrich K Trefz |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Regulatory toxicology and pharmacology : RTP Volume: 35 ISSN: 0273-2300 ISO Abbreviation: Regul. Toxicol. Pharmacol. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-08-15 Completed Date: 2002-12-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8214983 Medline TA: Regul Toxicol Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: S1-93 Citation Subset: IM |
Affiliation:
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Medical and Scientific Affairs, The NutraSweet Company, Mt Prospect, Illinois 60056, USA. harriett.h.butchko@nutrasweet.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Affect
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drug effects Animals Aspartame / administration & dosage, adverse effects*, metabolism, toxicity Behavior / drug effects Brain Neoplasms / chemically induced Cognition / drug effects Drug Evaluation, Preclinical Drug Hypersensitivity / etiology Electroencephalography / drug effects Endocrine System / drug effects Headache / chemically induced Humans Methanol / metabolism Phenylalanine / metabolism Product Surveillance, Postmarketing Seizures / chemically induced Sweetening Agents / administration & dosage, adverse effects*, metabolism, toxicity Weight Loss / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Sweetening Agents; 22839-47-0/Aspartame; 63-91-2/Phenylalanine; 67-56-1/Methanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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