Document Detail


Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers.
MedLine Citation:
PMID:  22842475     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pressure-induced vasodilation (PIV) delays the decrease in cutaneous blood flow produced by local application of low pressure to the skin, a physiologically appropriate adjustment of local vasomotor function. Individuals without a normal PIV response have a high risk of ulceration. Here we demonstrate that acid-sensing ion channel 3 (Asic3) is an essential neuronal sensor for the vasodilation response to direct pressure in both humans and rodents and for protecting against pressure ulcers in mice.
Authors:
Bérengère Fromy; Eric Lingueglia; Dominique Sigaudo-Roussel; Jean Louis Saumet; Michel Lazdunski
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-29
Journal Detail:
Title:  Nature medicine     Volume:  -     ISSN:  1546-170X     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502015     Medline TA:  Nat Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1] Institut de Biologie et Chimie des Protéines, Centre National de la Recherche Scientifique (CNRS) FRE 3310, Lyon, France. [2] Université de Lyon 1, FRE 3310, Lyon, France.
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