Document Detail


Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model.
MedLine Citation:
PMID:  22939261     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Wound healing proceeds through a complex collaborative process involving many types of cells. Keratinocytes and fibroblasts of epidermal and dermal layers of the skin play prominent roles in this process. Asiaticoside, an active component of Centella asiatica, is known for beneficial effects on keloid and hypertrophic scar. However, the effects of this compound on normal human skin cells are not well known. Using in vitro systems, we observed the effects of asiaticoside on normal human skin cell behaviors related to healing. In a wound closure seeding model, asiaticoside increased migration rates of skin cells. By observing the numbers of cells attached and the area occupied by the cells, we concluded that asiaticoside also enhanced the initial skin cell adhesion. In cell proliferation assays, asiaticoside induced an increase in the number of normal human dermal fibroblasts. In conclusion, asiaticoside promotes skin cell behaviors involved in wound healing; and as a bioactive component of an artificial skin, may have therapeutic value.
Authors:
Jeong-Hyun Lee; Hye-Lee Kim; Mi Hee Lee; Kyung Eun You; Byeong-Ju Kwon; Hyok Jin Seo; Jong-Chul Park
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-29
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  -     ISSN:  1618-095X     ISO Abbreviation:  Phytomedicine     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier GmbH. All rights reserved.
Affiliation:
Department of Medical Engineering, Yonsei University College of Medicine, Shinchon-dong, Seodaemun-gu, Seoul 120-752, Republic of Korea; Brain Korea 21 for Medical Science, Yonsei University College of Medicine, Shinchon-dong, Seodaemun-gu, Seoul 120-752, Republic of Korea.
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